History of the development of antagonists for neuromuscular blocking agents

• Published in: Journal of anesthesia Vol. 34; no. 5; pp. 723 - 728
• Main Authors: Suzuki, Keiko, Takazawa, Tomonori, Saito, Shigeru
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.10.2020; Springer
• Subjects: Androstanols; Anesthesiology; Critical Care Medicine; Cysteine; Emergency Medicine; Enzyme inhibitors; gamma-Cyclodextrins - adverse effects; Homeopathy; Intensive; Materia medica and therapeutics; Medicine; Medicine & Public Health; Neostigmine; Neuromuscular Blockade; Neuromuscular blocking agents; Neuromuscular Blocking Agents - adverse effects; Neuromuscular Nondepolarizing Agents - adverse effects; Pain Medicine; Special Article; Sugammadex; Therapeutics; United Kingdom; Japan; Acetylcholinesterase inhibitor; Neostigmine; Sugammadex; Non-depolarizing neuromuscular blocking drug

Muscle relaxation induced by neuromuscular blocking agents (NMBAs) is necessary for tracheal intubation and immobilization during surgery. Although acetylcholinesterase inhibitors have been successfully used as antagonists for NMBAs, they have their limitations; their effects are transient and ineff...