Long-term changes in hippocampal n-methyl- d-aspartate receptor subunits following unilateral vestibular damage in rat

• Published in: Neuroscience Vol. 117; no. 4; pp. 965 - 970
• Main Authors: Liu, P, Zheng, Y, King, J, Darlington, C.L, Smith, P.F
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.01.2003; Elsevier
• Subjects: AMPA; Animals; Biological and medical sciences; Denervation; Dentate Gyrus - metabolism; Dentate Gyrus - physiopathology; Down-Regulation - physiology; Functional Laterality - physiology; Fundamental and applied biological sciences. Psychology; hippocampus; Hippocampus - metabolism; Hippocampus - physiopathology; Immunohistochemistry; labyrinth; Memory Disorders - etiology; Memory Disorders - pathology; Memory Disorders - physiopathology; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; NMDA; Rats; Receptors, AMPA - metabolism; Receptors, N-Methyl-D-Aspartate - metabolism; Synaptic Transmission - physiology; unilateral vestibular deafferentation; Vertebrates: nervous system and sense organs; Vestibular Diseases - complications; Vestibule, Labyrinth - injuries; Vestibule, Labyrinth - physiopathology; unilateral vestibular deafferentation; UVD; AMPA; hippocampus; nNOS; SHAM; NMDA; LTP; SN; CONT; Rat; Rodentia; Central nervous system; Labyrinth; Glutamate receptor; Subunit; Vertebrata; Mammalia; Vestibular system; Deafferentation; NMDA receptor; Hippocampus; Brain (vertebrata)

Previous studies have indicated that damage to the peripheral vestibular system results in dysfunction of hippocampal place cells and an impairment of spatial learning and memory. The aim of this study was to determine whether lesions of one vestibular labyrinth (unilateral vestibular deafferentatio...