Oncolytic Avian Reovirus σA-Modulated Upregulation of the HIF-1α/C-myc/glut1 Pathway to Produce More Energy in Different Cancer Cell Lines Benefiting Virus Replication

• Published in: Viruses Vol. 15; no. 2; p. 523
• Main Authors: Hsu, Chao-Yu, Huang, Jing-Wen, Huang, Wei-Ru, Chen, I-Chun, Chen, Ming-Shan, Liao, Tsai-Ling, Chang, Yu-Kang, Munir, Muhammad, Liu, Hung-Jen
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.02.2023; MDPI
• Subjects: Analysis; Antibodies; Autophagy; Avian orthoreovirus; avian reoviruses; c-myc; c-Myc protein; Cancer; Cancer cells; Cancer therapies; Cell metabolism; Cells; Dehydrogenases; energy; Fermentation; fluorescent antibody technique; glut1; Glutamic Acid; Glutaminase; Glycolysis; Growth; HeLa Cells; HIF-1α; Humans; Hypoxia-inducible factor 1a; Immunofluorescence; Immunotherapy; Infections; Influence; Ketoglutaric acid; Kinases; L-Lactate dehydrogenase; Laboratories; lactate dehydrogenase; Lactates; Lactic acid; lactic fermentation; Metabolic pathways; Metabolism; mRNA; Myc protein; neoplasm cells; Neoplasms; Oncolysis; oncolytic virus; Orthoreovirus, Avian; Physiological aspects; Plasmids; Proteins; Reagents; Replication; Signal Transduction; structural proteins; Structure; Tricarboxylic acid cycle; Tumor cell lines; Up-Regulation; Viral proteins; Virus Replication; Viruses; Western blotting; Taiwan; United States > US; glut1; c-myc; oncolytic virus; glycolysis; HIF-1α; avian reoviruses; ATeams

Our previous reports proved that the structural protein σA of avian reovirus (ARV) is an energy activator which can regulate cellular metabolism that is essential for virus replication. This study has further demonstrated that the ARV protein σA is able to upregulate the HIF-1α/myc/glut1 pathway in...