Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 51; pp. E5508 - E5517
• Main Authors: Novoa, Eva Maria, Camacho, Noelia, Tor, Anna, Wilkinson, Barrie, Moss, Steven, Marín-García, Patricia, Azcárate, Isabel G., Bautista, José M., Mirando, Adam C., Francklyn, Christopher S., Varon, Sònia, Royo, Miriam, Cortés, Alfred, Ribas de Pouplana, Lluís
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 23.12.2014; National Acad Sciences
• Series: PNAS Plus
• Subjects: Amino Acyl-tRNA Synthetases - antagonists & inhibitors; Animals; Antimalarials - pharmacology; Antimalarials - therapeutic use; Bioengineering; Biological Sciences; Biosynthesis; Cytotoxicity; Drug resistance; Enzyme Inhibitors - pharmacology; Enzyme Inhibitors - therapeutic use; Humans; Malaria; Malaria, Falciparum - drug therapy; Mice; Parasitic protozoa; Plasmodium falciparum; Plasmodium falciparum - drug effects; PNAS Plus; RNA-protein interactions; malaria; drug design; aminoacyl-tRNA synthetase; borrelidin; plasmodium

Significance Malaria remains one of the main health threats in the developing world, with staggering social and economic costs. Resistance to artemisins, the main pharmacological tool currently available against malaria, has been widely reported. Borrelidin, a natural compound that inhibits threonyl...