Cerebrospinal fluid ctDNA and metabolites are informative biomarkers for the evaluation of CNS germ cell tumors

• Published in: Scientific Reports Vol. 10; no. 1; p. 14326
• Main Authors: Takayasu, Takeshi, Shah, Mauli, Dono, Antonio, Yan, Yuanqing, Borkar, Roshan, Putluri, Nagireddy, Zhu, Jay-Jiguang, Hama, Seiji, Yamasaki, Fumiyuki, Tahara, Hidetoshi, Sugiyama, Kazuhiko, Kurisu, Kaoru, Esquenazi, Yoshua, Ballester, Leomar Y.
• Format: Journal Article
• Language: English
• Published: London Springer Science and Business Media LLC 31.08.2020; Nature Publishing Group UK; Nature Publishing Group
• Subjects: 631/67/1679; 631/67/1922; 631/67/2327; 631/67/395; Acetic acid; Biomarkers, Tumor; Biomarkers, Tumor - cerebrospinal fluid; Biomarkers, Tumor - genetics; Case-Control Studies; Central nervous system; Central Nervous System Neoplasms; Central Nervous System Neoplasms - cerebrospinal fluid; Central Nervous System Neoplasms - genetics; Cerebrospinal fluid; Cerebrovascular system; Circulating Tumor DNA; Circulating Tumor DNA - cerebrospinal fluid; Circulating Tumor DNA - genetics; Cortex; Humanities and Social Sciences; Humans; Liquid chromatography; Mass spectrometry; Metabolites; multidisciplinary; Neoplasms, Germ Cell and Embryonal; Neoplasms, Germ Cell and Embryonal - cerebrospinal fluid; Neoplasms, Germ Cell and Embryonal - genetics; Perfusion; Science; Science (multidisciplinary); Traumatic brain injury; Tumors; Urea

Serum and cerebrospinal fluid (CSF) levels of α-fetoprotein and β-subunit of human chorionic gonadotropin are used as biomarkers for the management of central nervous system (CNS) germ cell tumors (GCTs). However, additional discriminating biomarkers are required. Especially, biomarkers to different...