Structural basis of histone H3K27 trimethylation by an active polycomb repressive complex 2 - Jiao, Lianying; Liu, Xin (Science (American Association for the Advancement of Science), 2015)
Keywords: Allosteric Regulation; Amino Acid Sequence; Cancer; Catalysis; Catalytic Domain; Chaetomium - genetics; Chaetomium - metabolism; Contact; Crystal structure; Crystallization; Crystallography, X-Ray; Enzymatic activity; Feedback (Response); Fungal Proteins - antagonists & inhibitors; Fungal Proteins - chemistry; Fungal Proteins - metabolism; Gene Silencing; Genes; Histones; Histones - metabolism; Humans; Jumonji Domain-Containing Histone Demethylases - metabolism; Literary Devices; Lysine; Methylation; Molecular Sequence Data; Mutation; Neoplasms - genetics; Peptides; Polycomb Repressive Complex 2 - antagonists & inhibitors; Polycomb Repressive Complex 2 - chemistry; Polycomb Repressive Complex 2 - metabolism; Protein Structure, Tertiary; RESEARCH ARTICLE SUMMARY; S-Adenosylhomocysteine - chemistry; S-Adenosylhomocysteine - metabolism; Stimulation; Structural analysis; Structural Analysis (Linguistics); Structural Analysis (Science); Transcription, Genetic; Yeast; Yeasts