Neural Stem Cell-Based Therapy for Ischemic Stroke

Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impai...

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Published inTranslational stroke research Vol. 2; no. 3; pp. 272 - 278
Main Authors Kokaia, Zaal, Darsalia, Vladimer
Format Journal Article
LanguageEnglish
Published New York Springer-Verlag 01.09.2011
Springer Nature B.V
Subjects
Ablation
Biomedical and Life Sciences
Biomedicine
Brain research
Cardiology
Cell growth
Cell-based Therapies for Stroke
Clinical Medicine
Clinical translation
Cytokines
Growth factors
Ischemia
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
Neurogenesis
Neurologi
Neurology
Neuroregeneration
Neurosciences
Neurosurgery
Rodents
Stem cell transplantation
Stem cells
Stroke
Transplantation
Traumatic brain injury
Vascular Surgery
Clinical translation
Stroke
Transplantation
Neurogenesis
Neuroregeneration
Stem cells
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Abstract Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell transplantation have been completed or are on-going but the results have not yet proven the effectiveness of the stem cell-based approaches. A joint effort of stroke researchers and clinicians is needed to further optimize treatment protocols using safe and reproducible stem cell sources tested in relevant animal models of stroke and showing substantial neurological recovery of stroke-impaired function.
AbstractList Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell transplantation have been completed or are on-going but the results have not yet proven the effectiveness of the stem cell-based approaches. A joint effort of stroke researchers and clinicians is needed to further optimize treatment protocols using safe and reproducible stem cell sources tested in relevant animal models of stroke and showing substantial neurological recovery of stroke-impaired function.
Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell transplantation have been completed or are on-going but the results have not yet proven the effectiveness of the stem cell-based approaches. A joint effort of stroke researchers and clinicians is needed to further optimize treatment protocols using safe and reproducible stem cell sources tested in relevant animal models of stroke and showing substantial neurological recovery of stroke-impaired function.Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental evidence, stem cell-based therapy is a very promising prospect for the development of a novel treatment to restore stroke-damaged brain and impaired neurological function. Studies performed on experimental animal models of stroke employed a variety of stem cell types from diverse sources and have demonstrated their ability to replace lost neurons and functionally integrate into the brain, modulate inflammation, and stimulate angiogenesis and neurogenesis from an endogenous stem cell pool, most likely through trophic actions. A few clinical trials in stroke patients using stem cell transplantation have been completed or are on-going but the results have not yet proven the effectiveness of the stem cell-based approaches. A joint effort of stroke researchers and clinicians is needed to further optimize treatment protocols using safe and reproducible stem cell sources tested in relevant animal models of stroke and showing substantial neurological recovery of stroke-impaired function.
Author Darsalia, Vladimer
Kokaia, Zaal
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Snippet Stem cell-based approaches for the treatment of stroke have been the subject of intensive research over the past decade. Based on accumulated experimental...
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SubjectTerms Ablation
Biomedical and Life Sciences
Biomedicine
Brain research
Cardiology
Cell growth
Cell-based Therapies for Stroke
Clinical Medicine
Clinical translation
Cytokines
Growth factors
Ischemia
Klinisk medicin
Medical and Health Sciences
Medicin och hälsovetenskap
Neurogenesis
Neurologi
Neurology
Neuroregeneration
Neurosciences
Neurosurgery
Rodents
Stem cell transplantation
Stem cells
Stroke
Transplantation
Traumatic brain injury
Vascular Surgery
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Title Neural Stem Cell-Based Therapy for Ischemic Stroke
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