Up-regulation of annexin A2 in cholangiocarcinoma caused by Opisthorchis viverrini and its implication as a prognostic marker

• Published in: International journal for parasitology Vol. 40; no. 10; pp. 1203 - 1212
• Main Authors: Yonglitthipagon, Ponlapat, Pairojkul, Chawalit, Chamgramol, Yaovalux, Mulvenna, Jason, Sripa, Banchob
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Kidlington Elsevier Ltd 15.08.2010; [Oxford; New York]: Elsevier Science; Elsevier
• Subjects: Animals; Annexin; Annexin A2 - genetics; Annexin A2 - metabolism; ANXA2; bile ducts; Biological and medical sciences; Biomarkers, Tumor; Cell Line, Tumor; Cholangiocarcinoma; Cholangiocarcinoma - metabolism; Fundamental and applied biological sciences. Psychology; gene expression regulation; Gene Expression Regulation, Neoplastic; humans; hydrophobicity; Life cycle. Host-agent relationship. Pathogenesis; liver flukes; matrix-assisted laser desorption-ionization mass spectrometry; membrane proteins; metastasis; microarray technology; monoclonal antibodies; mortality; neoplasm cells; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; neoplasms; Opisthorchis - physiology; Opisthorchis viverrini; patients; prediction; Prognotic marker; Protein Array Analysis; protein synthesis; Proteomics; Protozoa; Thailand; Up-Regulation; Thailand; Prognotic marker; ANXA2; Opisthorchis viverrini; Annexin; Cholangiocarcinoma; Proteomics; Helmintha; Plathelmintha; Parasite; Marker; Invertebrata; Trematoda

Cholangiocarcinoma (CCA), or cancer of the bile ducts, is primarily associated with infection with the liver fluke Opisthorchis viverrini in northeast Thailand. The disease is associated with late presentation, poses challenges for diagnosis and has a high mortality rate – features that highlight th...