Cadherin Expression and EMT: A Focus on Gliomas

• Published in: Biomedicines Vol. 9; no. 10; p. 1328
• Main Authors: Noronha, Carolina, Ribeiro, Ana Sofia, Taipa, Ricardo, Castro, Diogo S., Reis, Joaquim, Faria, Cláudia, Paredes, Joana
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 26.09.2021; MDPI
• Subjects: Apoptosis; Binding sites; Brain tumors; cadherins; Cancer; Cell adhesion; Cell adhesion & migration; Cell growth; Cell migration; E-cadherin; EMT; Gene expression; Glioma; gliomas; Homeostasis; Invasiveness; Mesenchyme; Morphogenesis; N-Cadherin; Nervous system; Physiology; Polarity; Prostate; Proteins; Review; Stem cells

Cadherins are calcium-binding proteins with a pivotal role in cell adhesion and tissue homeostasis. The cadherin-dependent mechanisms of cell adhesion and migration are exploited by cancer cells, contributing to tumor invasiveness and dissemination. In particular, cadherin switch is a hallmark of ep...