Structural basis for concerted recruitment and activation of IRF-3 by innate immune adaptor proteins - Zhao, Baoyu; Shu, Chang; Gao, Xinsheng; Sankaran, Banumathi; Du, Fenglei; Shelton, Catherine L.; Herr, Andrew B.; Ji, Jun-Yuan; Li, Pingwei (Proceedings of the National Academy of Sciences - PNAS, 2016)
Keywords: 60 APPLIED LIFE SCIENCES; Adaptor Proteins, Signal Transducing - chemistry; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - immunology; Adaptor Proteins, Vesicular Transport - chemistry; Adaptor Proteins, Vesicular Transport - genetics; Adaptor Proteins, Vesicular Transport - immunology; Amino Acid Motifs; BASIC BIOLOGICAL SCIENCES; Binding sites; Biological Sciences; CREB-Binding Protein - chemistry; CREB-Binding Protein - genetics; CREB-Binding Protein - immunology; crystal structure; Cytokines; Gene expression; Humans; Immune Evasion; Immunity, Innate; innate immunity; Interferon Regulatory Factor-3 - chemistry; Interferon Regulatory Factor-3 - genetics; Interferon Regulatory Factor-3 - immunology; Membrane Proteins - chemistry; Membrane Proteins - genetics; Membrane Proteins - immunology; Phosphorylation; PNAS Plus; Protein Domains; Proteins; Reoviridae; Rotavirus - chemistry; Rotavirus - genetics; Rotavirus - immunology; Rotavirus Infections - genetics; Rotavirus Infections - immunology; Signal transduction; signaling; transcription factor; type I interferon; Viral Nonstructural Proteins - chemistry; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - immunology; type I interferon; crystal structure; transcription factor; signaling; innate immunity