Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation

• Published in: Kidney international Vol. 88; no. 4; pp. 711 - 721
• Main Authors: Zhao, Yang, Zhao, Ming-Ming, Cai, Yan, Zheng, Ming-Fei, Sun, Wei-Liang, Zhang, Song-Yang, Kong, Wei, Gu, Jun, Wang, Xian, Xu, Ming-Jiang
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2015; Elsevier Limited
• Subjects: aging; Animals; Aorta, Abdominal - drug effects; Aorta, Abdominal - enzymology; Aorta, Abdominal - pathology; Aorta, Thoracic - drug effects; Aorta, Thoracic - enzymology; Aorta, Thoracic - pathology; Aortic Diseases - enzymology; Aortic Diseases - genetics; Aortic Diseases - pathology; Aortic Diseases - prevention & control; Cells, Cultured; chronic renal failure; Disease Models, Animal; Gene Expression Regulation; Genetic Predisposition to Disease; Glucuronidase - deficiency; Glucuronidase - genetics; Glucuronidase - metabolism; Humans; inorganic phosphate; Kidney Failure, Chronic - drug therapy; Kidney Failure, Chronic - enzymology; Kidney Failure, Chronic - pathology; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - enzymology; Muscle, Smooth, Vascular - metabolism; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Osteogenesis - drug effects; Phenotype; Protein Kinase Inhibitors - pharmacology; RNA Interference; Signal Transduction - drug effects; Sirolimus - pharmacology; Time Factors; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Transfection; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Vascular Calcification - enzymology; Vascular Calcification - genetics; Vascular Calcification - pathology; Vascular Calcification - prevention & control; vascular smooth muscle cell; inorganic phosphate; aging; vascular smooth muscle cell; chronic renal failure

Vascular calcification (VC) is a major risk factor for cardiovascular mortality in chronic renal failure (CRF) patients, but the pathogenesis remains partially unknown and effective therapeutic targets should be urgently explored. Here we pursued the therapeutic role of rapamycin in CRF-related VC....