Mammalian target of rapamycin signaling inhibition ameliorates vascular calcification via Klotho upregulation - Zhao, Yang; Zhao, Ming-Ming; Cai, Yan; Zheng, Ming-Fei; Sun, Wei-Liang; Zhang, Song-Yang; Kong, Wei; Gu, Jun; Wang, Xian; Xu, Ming-Jiang (Kidney international, 2015)
Keywords: aging; Animals; Aorta, Abdominal - drug effects; Aorta, Abdominal - enzymology; Aorta, Abdominal - pathology; Aorta, Thoracic - drug effects; Aorta, Thoracic - enzymology; Aorta, Thoracic - pathology; Aortic Diseases - enzymology; Aortic Diseases - genetics; Aortic Diseases - pathology; Aortic Diseases - prevention & control; Cells, Cultured; chronic renal failure; Disease Models, Animal; Gene Expression Regulation; Genetic Predisposition to Disease; Glucuronidase - deficiency; Glucuronidase - genetics; Glucuronidase - metabolism; Humans; inorganic phosphate; Kidney Failure, Chronic - drug therapy; Kidney Failure, Chronic - enzymology; Kidney Failure, Chronic - pathology; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - enzymology; Muscle, Smooth, Vascular - metabolism; Myocytes, Smooth Muscle - drug effects; Myocytes, Smooth Muscle - metabolism; Myocytes, Smooth Muscle - pathology; Osteogenesis - drug effects; Phenotype; Protein Kinase Inhibitors - pharmacology; RNA Interference; Signal Transduction - drug effects; Sirolimus - pharmacology; Time Factors; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Transfection; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Vascular Calcification - enzymology; Vascular Calcification - genetics; Vascular Calcification - pathology; Vascular Calcification - prevention & control; vascular smooth muscle cell; inorganic phosphate; aging; vascular smooth muscle cell; chronic renal failure