Inflammation context in Alzheimer’s disease, a relationship intricate to define

• Published in: Biological research Vol. 55; no. 1; pp. 39 - 18
• Main Authors: Novoa, Catalina, Salazar, Paulina, Cisternas, Pedro, Gherardelli, Camila, Vera-Salazar, Roberto, Zolezzi, Juan M., Inestrosa, Nibaldo C.
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.12.2022; BioMed Central; BMC
• Subjects: Advertising executives; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Development and progression; Humans; Inflammation; Inflammation - metabolism; Interleukins; Microglia; NF-kappa B - metabolism; Review; Tumor Necrosis Factor-alpha - metabolism; Type 2 diabetes; Canada

Alzheimer’s disease (AD), the most common form of dementia, is characterized by the accumulation of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates. Importantly, Aβ and tau species are able to activate astrocytes and microglia, which release several proinflammatory cytokines, such as t...