novel docking domain interface model predicting recombination between homoeologous modular biosynthetic gene clusters

• Published in: Journal of industrial microbiology & biotechnology Vol. 38; no. 9; pp. 1295 - 1304
• Main Authors: Starcevic, Antonio, Diminic, Janko, Zucko, Jurica, Elbekali, Mouhsine, Schlosser, Tobias, Lisfi, Mohamed, Vukelic, Ana, Long, Paul F, Hranueli, Daslav, Cullum, John
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.09.2011; Oxford University Press; Springer
• Subjects: Biochemistry; Bioinformatics; Biological and medical sciences; Biomedical and Life Sciences; Biosynthesis; Biotechnology; Chemistry; Chromosomes; enzymology; Evolution; Food science; Fundamental and applied biological sciences. Psychology; Genes, Bacterial; Genetic Engineering; genetics; Inorganic Chemistry; Life Sciences; ligases; metabolism; Metabolites; Microbiology; Models, Genetic; multigene family; new products; Original Paper; Peptide Synthases; Peptide Synthases - chemistry; Peptide Synthases - genetics; Peptide Synthases - metabolism; Plasmids; polyketide synthases; Polyketide Synthases - chemistry; Polyketide Synthases - genetics; Polyketide Synthases - metabolism; polyketides; Polypeptides; prediction; Protein Structure, Tertiary; Proteins; Recombination, Genetic; Streptomyces; Streptomyces - enzymology; Streptomyces - genetics; Studies; Substrate Specificity; Polyketide synthase; Non-ribosomal peptide synthetase; Chi sequence; Gene cluster; Recombination; Streptomycetaceae; Peptides; Enzyme; Streptomyces; Biosynthesis; Bacillaceae; Actinomycetales; Bacillales; Ligases; Bacillus; Bacteria; Actinomycetes; Models

An in silico model for homoeologous recombination between gene clusters encoding modular polyketide synthases (PKS) or non-ribosomal peptide synthetases (NRPS) was developed. This model was used to analyze recombination between 12 PKS clusters from Streptomyces species and related genera to predict...