Platelet imidazoline receptors as state marker of depressive symptomatology

• Published in: Journal of psychiatric research Vol. 42; no. 1; pp. 41 - 49
• Main Authors: Piletz, John, Baker, Robert, Halaris, Angelos
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.01.2008; Elsevier
• Subjects: Adult; Adult and adolescent clinical studies; Antidepressive Agents, Tricyclic - pharmacology; Biological and medical sciences; Blood Platelets - metabolism; Brief Psychiatric Rating Scale; Depression; Depressive Disorder - blood; Depressive Disorder - diagnosis; Depressive Disorder - drug therapy; Desipramine; Desipramine - pharmacology; Female; Gene Expression Regulation - drug effects; Gene Expression Regulation - physiology; Healthy subjects; Humans; Imidazoline receptors; Imidazoline Receptors - metabolism; Male; Medical sciences; Mood disorders; Neuropharmacology; Pharmacology. Drug treatments; Platelet Count; Psychiatry; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Radioligand Assay - methods; Reference Values; State marker; Time Factors; α 2-Adrenoceptors; Depression; Healthy subjects; Imidazoline receptors; State marker; Desipramine; α 2-Adrenoceptors; Mood disorder; Human; α2-Adrenergic receptor; Healthy subject; Psychotropic; Catecholamine; Tricyclic compound; Reuptake inhibitor; Imidazoline receptor; Symptomatology; Chemotherapy; Platelet; Treatment; α2-Adrenoceptors; Neurotransmitter; Antidepressant agent; Norepinephrine; Dibenzazepine derivatives

Previous studies have shown that imidazoline receptors (IR-1) are increased in platelets and frontal cortex of depressed patients, and this up-regulation is normalized (down-regulated) after antidepressant drug treatments. It has been hypothesized that IR-1 up-regulation during the depressive episod...