Aquaporin-4： orthogonal array assembly, CNS functions, and role in neuromyelitis optica

• Published in: Acta pharmacologica Sinica Vol. 32; no. 6; pp. 702 - 710
• Main Authors: Verkman, Alan S, Ratelade, Julien, Rossi, Andrea, Zhang, Hua, Tradtrantip, Lukmanee
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2011; Nature Publishing Group
• Subjects: Amino Acid Sequence; Animals; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - therapeutic use; Aquaporin 4; Aquaporin 4 - chemistry; Aquaporin 4 - immunology; Aquaporin 4 - physiology; Astrocytes; Autoantibodies; Biomedical and Life Sciences; Biomedicine; Brain; Brain injury; Cell migration; Central nervous system; Central Nervous System - immunology; Central Nervous System - metabolism; Central Nervous System - physiology; Demyelinating diseases; Drug Discovery; Edema; Glial fibrillary acidic protein; High-Throughput Screening Assays; Humans; Immunology; Immunoreactivity; Inflammation; Internal Medicine; Kidney; Lung; Medical Microbiology; Molecular Sequence Data; Neuromodulation; Neuromyelitis; Neuromyelitis Optica - drug therapy; Neuromyelitis Optica - immunology; Neuromyelitis Optica - metabolism; Neuronal-glial interactions; Permeability; Pharmacology/Toxicology; Plasma membranes; Protein Binding; Protein Multimerization; Review; Small Molecule Libraries - chemistry; Small Molecule Libraries - therapeutic use; Vaccine; 中枢神经系统; 星形胶质细胞; 正交表; 水通道蛋白4; 神经胶质; 胶质纤维酸性蛋白; 自身免疫性; 视神经; epilepsy; brain edema; transgenic mice; water transport; neuroinflammation; neuromyelitis optica; AQP4; neuroexcitation; astrocyte migration

Aquaporin-4 （AQP4） is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membra...