Aquaporin-4： orthogonal array assembly, CNS functions, and role in neuromyelitis optica

Aquaporin-4 （AQP4） is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membra...

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Published inActa pharmacologica Sinica Vol. 32; no. 6; pp. 702 - 710
Main Authors Verkman, Alan S, Ratelade, Julien, Rossi, Andrea, Zhang, Hua, Tradtrantip, Lukmanee
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.06.2011
Nature Publishing Group
Subjects
Amino Acid Sequence
Animals
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - therapeutic use
Aquaporin 4
Aquaporin 4 - chemistry
Aquaporin 4 - immunology
Aquaporin 4 - physiology
Astrocytes
Autoantibodies
Biomedical and Life Sciences
Biomedicine
Brain
Brain injury
Cell migration
Central nervous system
Central Nervous System - immunology
Central Nervous System - metabolism
Central Nervous System - physiology
Demyelinating diseases
Drug Discovery
Edema
Glial fibrillary acidic protein
High-Throughput Screening Assays
Humans
Immunology
Immunoreactivity
Inflammation
Internal Medicine
Kidney
Lung
Medical Microbiology
Molecular Sequence Data
Neuromodulation
Neuromyelitis
Neuromyelitis Optica - drug therapy
Neuromyelitis Optica - immunology
Neuromyelitis Optica - metabolism
Neuronal-glial interactions
Permeability
Pharmacology/Toxicology
Plasma membranes
Protein Binding
Protein Multimerization
Review
Small Molecule Libraries - chemistry
Small Molecule Libraries - therapeutic use
Vaccine
中枢神经系统
星形胶质细胞
正交表
水通道蛋白4
神经胶质
胶质纤维酸性蛋白
自身免疫性
视神经
epilepsy
brain edema
transgenic mice
water transport
neuroinflammation
neuromyelitis optica
AQP4
neuroexcitation
astrocyte migration
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Abstract Aquaporin-4 （AQP4） is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membranes in supramolecular structures called orthogonal arrays of particles （OAPs）. Phenotype analysis of AQP4-null mice indicates the involvement of AQP4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation. AQP4-nuil mice manifest reduced brain swelling in cytotoxic cerebral edema, but increased brain swelling in vasogenic edema and hydrocephalus. AQP4 deficiency also increases seizure duration, impairs glial scarring, and reduces the severity of autoimmune neuroinflammation. Each of these phenotypes is likely explicable on the basis of reduced astrocyte water permeability in AQP4 deficiency. AQP4 is also involved in the neuroinflammatory demyelinating disease neuromyelitis optica （NMO）, where autoantibodies （NMO-IgG） targeting AQP4 produce astrocyte damage and inflammation. Mice administered NMO-IgG and human complement by intracerebral injection develop characteristic NMO lesions with neuroinflammation, demyelination, perivascular complement deposition and loss of glial fibrillary acidic protein and AQP4 immunoreactivity. Our findings suggest the potential utility of AQP4-based therapeutics, including small-molecule modulators of AQP4 water transport function for therapy of brain swelling, injury and epilepsy, as well as small-molecule or monoclonal antibody blockers of NMO-IgG binding to AQP4 for therapy of NMO.
AbstractList Aquaporin-4 (AQP4) is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membranes in supramolecular structures called orthogonal arrays of particles (OAPs). Phenotype analysis of AQP4-null mice indicates the involvement of AQP4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation. AQP4-null mice manifest reduced brain swelling in cytotoxic cerebral edema, but increased brain swelling in vasogenic edema and hydrocephalus. AQP4 deficiency also increases seizure duration, impairs glial scarring, and reduces the severity of autoimmune neuroinflammation. Each of these phenotypes is likely explicable on the basis of reduced astrocyte water permeability in AQP4 deficiency. AQP4 is also involved in the neuroinflammatory demyelinating disease neuromyelitis optica (NMO), where autoantibodies (NMO-IgG) targeting AQP4 produce astrocyte damage and inflammation. Mice administered NMO-IgG and human complement by intracerebral injection develop characteristic NMO lesions with neuroinflammation, demyelination, perivascular complement deposition and loss of glial fibrillary acidic protein and AQP4 immunoreactivity. Our findings suggest the potential utility of AQP4-based therapeutics, including small-molecule modulators of AQP4 water transport function for therapy of brain swelling, injury and epilepsy, as well as small-molecule or monoclonal antibody blockers of NMO-IgG binding to AQP4 for therapy of NMO.
Aquaporin-4 （AQP4） is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membranes in supramolecular structures called orthogonal arrays of particles （OAPs）. Phenotype analysis of AQP4-null mice indicates the involvement of AQP4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation. AQP4-nuil mice manifest reduced brain swelling in cytotoxic cerebral edema, but increased brain swelling in vasogenic edema and hydrocephalus. AQP4 deficiency also increases seizure duration, impairs glial scarring, and reduces the severity of autoimmune neuroinflammation. Each of these phenotypes is likely explicable on the basis of reduced astrocyte water permeability in AQP4 deficiency. AQP4 is also involved in the neuroinflammatory demyelinating disease neuromyelitis optica （NMO）, where autoantibodies （NMO-IgG） targeting AQP4 produce astrocyte damage and inflammation. Mice administered NMO-IgG and human complement by intracerebral injection develop characteristic NMO lesions with neuroinflammation, demyelination, perivascular complement deposition and loss of glial fibrillary acidic protein and AQP4 immunoreactivity. Our findings suggest the potential utility of AQP4-based therapeutics, including small-molecule modulators of AQP4 water transport function for therapy of brain swelling, injury and epilepsy, as well as small-molecule or monoclonal antibody blockers of NMO-IgG binding to AQP4 for therapy of NMO.
Aquaporin-4 (AQP4) is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membranes in supramolecular structures called orthogonal arrays of particles (OAPs). Phenotype analysis of AQP4-null mice indicates the involvement of AQP4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation. AQP4-null mice manifest reduced brain swelling in cytotoxic cerebral edema, but increased brain swelling in vasogenic edema and hydrocephalus. AQP4 deficiency also increases seizure duration, impairs glial scarring, and reduces the severity of autoimmune neuroinflammation. Each of these phenotypes is likely explicable on the basis of reduced astrocyte water permeability in AQP4 deficiency. AQP4 is also involved in the neuroinflammatory demyelinating disease neuromyelitis optica (NMO), where autoantibodies (NMO-IgG) targeting AQP4 produce astrocyte damage and inflammation. Mice administered NMO-IgG and human complement by intracerebral injection develop characteristic NMO lesions with neuroinflammation, demyelination, perivascular complement deposition and loss of glial fibrillary acidic protein and AQP4 immunoreactivity. Our findings suggest the potential utility of AQP4-based therapeutics, including small-molecule modulators of AQP4 water transport function for therapy of brain swelling, injury and epilepsy, as well as small-molecule or monoclonal antibody blockers of NMO-IgG binding to AQP4 for therapy of NMO.Aquaporin-4 (AQP4) is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membranes in supramolecular structures called orthogonal arrays of particles (OAPs). Phenotype analysis of AQP4-null mice indicates the involvement of AQP4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation. AQP4-null mice manifest reduced brain swelling in cytotoxic cerebral edema, but increased brain swelling in vasogenic edema and hydrocephalus. AQP4 deficiency also increases seizure duration, impairs glial scarring, and reduces the severity of autoimmune neuroinflammation. Each of these phenotypes is likely explicable on the basis of reduced astrocyte water permeability in AQP4 deficiency. AQP4 is also involved in the neuroinflammatory demyelinating disease neuromyelitis optica (NMO), where autoantibodies (NMO-IgG) targeting AQP4 produce astrocyte damage and inflammation. Mice administered NMO-IgG and human complement by intracerebral injection develop characteristic NMO lesions with neuroinflammation, demyelination, perivascular complement deposition and loss of glial fibrillary acidic protein and AQP4 immunoreactivity. Our findings suggest the potential utility of AQP4-based therapeutics, including small-molecule modulators of AQP4 water transport function for therapy of brain swelling, injury and epilepsy, as well as small-molecule or monoclonal antibody blockers of NMO-IgG binding to AQP4 for therapy of NMO.
Author Alan S VERKMAN Julien RATELADE Andrea ROSSI Hua ZHANG Lukmanee TRADTRANTIP
AuthorAffiliation Departments of Medicine and Physiology, University of California, San Francisco, CA 94143-0521, USA
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  organization: Departments of Medicine and Physiology, University of California
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  organization: Departments of Medicine and Physiology, University of California
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/21552296$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1074/jbc.271.9.4577
10.1152/ajprenal.00439.2003
10.1083/jcb.60.1.316
10.1038/72256
10.1074/jbc.M109.071670
10.1016/j.neuroscience.2010.01.053
10.1016/j.ygeno.2007.12.003
10.1016/j.bpj.2009.09.017
10.1021/bi970231r
10.1096/fj.06-5930fje
10.1016/S1474-4422(07)70216-8
10.1096/fj.06-6848com
10.1529/biophysj.107.115121
10.1097/WNR.0b013e3282f2b4eb
10.1074/jbc.272.26.16140
10.1016/0014-4827(74)90670-3
10.1038/sj.jcbfm.9600306
10.1096/fj.04-1723fje
10.1096/fj.10-177279
10.1002/glia.20855
10.1242/jcs.110.22.2855
10.1007/s00109-008-0303-9
10.1523/JNEUROSCI.17-01-00171.1997
10.1074/jbc.270.39.22907
10.1073/pnas.91.26.13052
10.1074/jbc.M111.227298
10.1038/nmeth801
10.1073/pnas.95.20.11981
10.1038/nature03550
10.1016/j.neuroscience.2004.08.053
10.1002/ana.21802
10.1096/fj.02-1183fje
10.1016/j.bpj.2010.06.023
10.1091/mbc.e08-03-0322
10.1093/brain/awp309
10.1073/pnas.93.20.10908
10.1172/JCI231
10.1073/pnas.0902725106
10.1016/j.neulet.2006.05.004
10.1016/j.neuroscience.2009.03.069
10.1073/pnas.2336064100
10.1002/glia.20318
10.1242/jcs.042341
10.1016/j.neulet.2008.10.065
10.1523/JNEUROSCI.2294-04.2004
10.1111/j.1471-4159.2005.03362.x
10.1002/ana.21837
10.1002/glia.21177
10.1074/jbc.M104368200
10.1093/brain/awn014
10.1074/jbc.M413627200
10.1242/jcs.02680
10.1523/JNEUROSCI.0257-08.2008
10.1007/s00424-007-0357-5
10.1212/01.WNL.0000289761.64862.ce
10.1007/978-3-540-79885-9_3
10.1017/S1461145711000022
10.1073/pnas.1012867108
10.1021/bi990941s
10.1073/pnas.92.10.4328
10.1096/fj.07-104836
10.1016/j.jmb.2005.10.081
10.1212/01.wnl.0000216139.44259.74
10.1074/jbc.M109.093948
10.1038/jcbfm.2010.163
10.1074/jbc.M801425200
10.1084/jem.20050304
10.1074/jbc.M703236200
10.1016/j.mcn.2007.08.007
10.1073/pnas.2235843100
10.1016/S0021-9258(17)37486-0
10.1007/978-3-540-79885-9_2
10.1002/cm.20357
10.1038/nature03460
10.1186/1471-2202-10-94
10.1096/fj.07-9468com
10.1038/nrn1326
10.1371/journal.pone.0010455
10.1016/j.bbrc.2009.06.085
10.1084/jem.20081241
10.1242/jcs.108.9.2993
10.1002/ana.22023
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IsDoiOpenAccess true
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Issue 6
Keywords epilepsy
brain edema
transgenic mice
water transport
neuroinflammation
neuromyelitis optica
AQP4
neuroexcitation
astrocyte migration
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c569t-57baf987c546d2fd2b03cf35b86ebab9827fa354de232dd28054bf6ed7c78c2a3
Notes AQP4; water transport; transgenic mice; brain edema; astrocyte migration; neuroexcitation; neuroinflammation; epilepsy; neuromyelitis optica
Aquaporin-4 （AQP4） is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle. The two AQP4 isoforms produced by alternative spicing, M1 and M23 AQP4, form heterotetramers that assemble in cell plasma membranes in supramolecular structures called orthogonal arrays of particles （OAPs）. Phenotype analysis of AQP4-null mice indicates the involvement of AQP4 in brain and spinal cord water balance, astrocyte migration, neural signal transduction and neuroinflammation. AQP4-nuil mice manifest reduced brain swelling in cytotoxic cerebral edema, but increased brain swelling in vasogenic edema and hydrocephalus. AQP4 deficiency also increases seizure duration, impairs glial scarring, and reduces the severity of autoimmune neuroinflammation. Each of these phenotypes is likely explicable on the basis of reduced astrocyte water permeability in AQP4 deficiency. AQP4 is also involved in the neuroinflammatory demyelinating disease neuromyelitis optica （NMO）, where autoantibodies （NMO-IgG） targeting AQP4 produce astrocyte damage and inflammation. Mice administered NMO-IgG and human complement by intracerebral injection develop characteristic NMO lesions with neuroinflammation, demyelination, perivascular complement deposition and loss of glial fibrillary acidic protein and AQP4 immunoreactivity. Our findings suggest the potential utility of AQP4-based therapeutics, including small-molecule modulators of AQP4 water transport function for therapy of brain swelling, injury and epilepsy, as well as small-molecule or monoclonal antibody blockers of NMO-IgG binding to AQP4 for therapy of NMO.
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OpenAccessLink http://journals.scholarsportal.info/openUrl.xqy?doi=10.1038/aps.2011.27
PMID 21552296
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  year: 2011
  text: 2011-06-01
  day: 01
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PublicationPlace London
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– name: Shanghai
PublicationTitle Acta pharmacologica Sinica
PublicationTitleAbbrev Acta Pharmacol Sin
PublicationTitleAlternate Acta Pharmacologica Sinica
PublicationYear 2011
Publisher Nature Publishing Group UK
Nature Publishing Group
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
References Silver, Miller (CR52) 2004; 5
Furman, Gorelick-Feldman, Davidson, Yasumura, Neely, Agre (CR25) 2003; 100
Hinson, Pittock, Lucchinetti, Roemer, Fryer, Kryzer (CR80) 2007; 69
Kinoshita, Nakatsuji, Kimura, Moriya, Takata, Okuno (CR78) 2009; 386
Ho, Yeh, Sandstrom, Chorny, Harries, Robbins (CR14) 2009; 106
Jung, Bhat, Preston, Guggino, Baraban, Agre (CR2) 1994; 91
Neely, Christensen, Nielsen, Agre (CR11) 1999; 38
Binder, Papadopoulos, Haggie, Verkman (CR64) 2004; 24
Nagelhus, Mathiisen, Ottersen (CR69) 2004; 129
Crane, Verkman (CR29) 2009; 97
Zador, Magzoub, Jin, Manley, Papadopoulos, Verkman (CR66) 2008; 22
Saadoun, Tait, Reza, Davies, Bell, Verkman (CR34) 2009; 161
Papadopoulos, Verkman (CR43) 2005; 280
Li, Zhang, Varrin-Doyer, Zamvil, Verkman (CR40) 2011; 25
Landis, Reese (CR17) 1974; 60
Crane, Lam, Rossi, Gupta, Bennett, Verkman (CR83) 2011; 286
Crane, Verkman (CR26) 2008; 94
Li, Zhang, Verkman (CR72) 2009; 10
Mader, Lutterotti, Di Pauli, Kuenz, Schanda, Aboul-Enein (CR75) 2010; 5
Crane, Van Hoek, Skach, Verkman (CR27) 2008; 19
Walz, Fujiyoshi, Engel (CR16) 2009; 190
Loitto, Karlsson, Magnusson (CR57) 2009; 66
Auguste, Jin, Uchida, Yan, Manley, Papadopoulos (CR53) 2007; 21
Ruiz-Ederra, Zhang, Verkman (CR70) 2007; 282
Yao, Hrabetova, Nicholson, Manley (CR65) 2008; 28
Nielsen, Nagelhus, Amiry-Moghaddam, Bourque, Agre, Ottersen (CR5) 1997; 17
Wu, Lu, Yan, Su, Wang, Liu (CR38) 2008; 448
Hiroaki, Tani, Kamegawa, Gyobu, Nishikawa, Suzuki (CR22) 2006; 355
Hub, Grubmuller, de Groot (CR15) 2009; 190
Lennon, Kryzer, Pittock, Verkman, Hinson (CR74) 2005; 202
Papadopoulos, Saadoun, Verkman (CR56) 2008; 456
Charras, Yarrow, Horton, Mahadevan, Mitchison (CR58) 2005; 435
Zhou, Kong, Hua, Xiao, Ding, Hu (CR35) 2008; 19
Liu, Lu, Kong, Li, Marshall, Xiao, Ding, Gao, Hu (CR37) 2011; 15
Hasegawa, Ma, Skach, Matthay, Verkman (CR1) 1994; 269
Saadoun, Papadopoulos, Hara-Chikuma, Verkman (CR51) 2005; 434
Binder, Yao, Zador, Sick, Verkman, Manley (CR62) 2006; 53
Wingerchuk, Lennon, Lucchinetti, Pittock, Weinshenker (CR73) 2007; 6
Manley, Fujimura, Ma, Noshita, Filiz, Bollen (CR32) 2000; 6
Tait, Saadoun, Bell, Verkman, Papadopoulos (CR47) 2010; 167
Zhang, Verkman (CR71) 2008; 37
Bradl, Misu, Takahashi, Watanabe, Mader, Reindl (CR77) 2009; 66
Frigeri, Gropper, Turck, Verkman (CR3) 1995; 92
Saadoun, Papadopoulos, Watanabe, Yan, Manley, Verkman (CR41) 2005; 118
Yang, Zador, Verkman (CR44) 2008; 283
Crane, Verkman (CR28) 2009; 122
Papadopoulos, Manley, Krishna, Verkman (CR33) 2004; 18
Kimura, Hsu, Seldin, Verkman, Scharfman, Binder (CR50) 2010; 67
Frigeri, Gropper, Umenishi, Kawashima, Brown, Verkman (CR4) 1995; 108
Crane, Bennett, Verkman (CR10) 2009; 284
Silberstein, Bouley, Huang, Fang, Pastor-Soler, Brown (CR23) 2004; 287
Li, Gao, Liu, Cao, Sun, Ding (CR36) 2006; 403
Padmawar, Yao, Bloch, Manley, Verkman (CR63) 2005; 2
Yang, Brown, Verkman (CR19) 1996; 271
Li, Verkman (CR60) 2001; 276
Amiry-Moghaddam, Williamson, Palomba, Eid, de Lanerolle, Nagelhus (CR68) 2003; 100
Bloch, Auguste, Manley, Verkman (CR48) 2006; 26
Rash, Staehelin, Ellisman (CR18) 1974; 86
Lu, Zhang, Zador, Verkman (CR61) 2008; 22
Badaut, Ashwal, Adami, Tone, Recker, Spagnoli (CR42) 2011; 31
Benfenati, Caprini, Dovizio, Mylonakou, Ferroni, Ottersen (CR45) 2011; 108
Yang, Ma, Verkman (CR7) 1995; 270
Saadoun, Bell, Verkman, Papadopoulos (CR49) 2008; 131
Li, Patil, Verkman (CR59) 2002; 43
Ma, Yang, Gillespie, Carlson, Epstein, Verkman (CR31) 1997; 100
Nicchia, Mastrototaro, Rossi, Pisani, Tortorella, Ruggieri (CR24) 2009; 57
Nicchia, Frigeri, Liuzzi, Svelto (CR39) 2003; 17
Verbavatz, Ma, Gobin, Verkman (CR20) 1997; 110
Verkman, Hara-Chikuma, Papadopoulos (CR54) 2008; 86
Lu, Lee, Smith, Jung, Agre, Verdijk (CR6) 1996; 93
Yang, van Hoek, Verkman (CR12) 1997; 36
Yang, Verkman (CR13) 1997; 272
Bloch, Papadopoulos, Manley, Verkman (CR46) 2005; 95
Zhang, Verkman (CR67) 2010; 99
Tajima, Crane, Verkman (CR30) 2010; 285
Rossi, Crane, Verkman (CR9) 2011; 59
Bennett, Lam, Kalluri, Saikali, Bautista, Dupree (CR76) 2009; 66
Wingerchuk, Lennon, Pittock, Lucchinetti, Weinshenker (CR82) 2006; 66
Rash, Yasumura, Hudson, Agre, Nielsen (CR21) 1998; 95
Moe, Sorbo, Sogaard, Zeuthen, Petter Ottersen, Holen (CR8) 2008; 91
Saadoun, Waters, Bell, Vincent, Verkman, Papadopoulos (CR79) 2010; 133
Hinson, Roemer, Lucchinetti, Fryer, Kryzer, Chamberlain (CR81) 2008; 205
Hu, Verkman (CR55) 2006; 20
GT Manley (BFaps201127_CR32) 2000; 6
J Li (BFaps201127_CR60) 2001; 276
MC Papadopoulos (BFaps201127_CR33) 2004; 18
MC Papadopoulos (BFaps201127_CR43) 2005; 280
B Yang (BFaps201127_CR19) 1996; 271
B Yang (BFaps201127_CR12) 1997; 36
DM Wingerchuk (BFaps201127_CR73) 2007; 6
B Yang (BFaps201127_CR7) 1995; 270
DC Lu (BFaps201127_CR61) 2008; 22
DK Binder (BFaps201127_CR64) 2004; 24
M Kinoshita (BFaps201127_CR78) 2009; 386
JM Verbavatz (BFaps201127_CR20) 1997; 110
GP Nicchia (BFaps201127_CR24) 2009; 57
JE Rash (BFaps201127_CR18) 1974; 86
DK Binder (BFaps201127_CR62) 2006; 53
J Zhou (BFaps201127_CR35) 2008; 19
O Bloch (BFaps201127_CR48) 2006; 26
J Silver (BFaps201127_CR52) 2004; 5
JS Jung (BFaps201127_CR2) 1994; 91
SE Moe (BFaps201127_CR8) 2008; 91
JM Crane (BFaps201127_CR29) 2009; 97
Lei Liu (BFaps201127_CR37) 2011; 15
JL Bennett (BFaps201127_CR76) 2009; 66
S Mader (BFaps201127_CR75) 2010; 5
JM Crane (BFaps201127_CR10) 2009; 284
JM Crane (BFaps201127_CR26) 2008; 94
S Saadoun (BFaps201127_CR49) 2008; 131
JD Neely (BFaps201127_CR11) 1999; 38
A Frigeri (BFaps201127_CR3) 1995; 92
JD Ho (BFaps201127_CR14) 2009; 106
S Saadoun (BFaps201127_CR79) 2010; 133
AS Verkman (BFaps201127_CR54) 2008; 86
JM Crane (BFaps201127_CR28) 2009; 122
SR Hinson (BFaps201127_CR80) 2007; 69
VM Loitto (BFaps201127_CR57) 2009; 66
H Zhang (BFaps201127_CR67) 2010; 99
GT Charras (BFaps201127_CR58) 2005; 435
T Walz (BFaps201127_CR16) 2009; 190
L Li (BFaps201127_CR40) 2011; 25
DM Wingerchuk (BFaps201127_CR82) 2006; 66
M Amiry-Moghaddam (BFaps201127_CR68) 2003; 100
SR Hinson (BFaps201127_CR81) 2008; 205
V Benfenati (BFaps201127_CR45) 2011; 108
L Li (BFaps201127_CR72) 2009; 10
H Zhang (BFaps201127_CR71) 2008; 37
JM Crane (BFaps201127_CR27) 2008; 19
A Kimura (BFaps201127_CR50) 2010; 67
S Saadoun (BFaps201127_CR51) 2005; 434
JE Rash (BFaps201127_CR21) 1998; 95
S Saadoun (BFaps201127_CR41) 2005; 118
N Wu (BFaps201127_CR38) 2008; 448
GP Nicchia (BFaps201127_CR39) 2003; 17
VA Lennon (BFaps201127_CR74) 2005; 202
S Nielsen (BFaps201127_CR5) 1997; 17
B Yang (BFaps201127_CR13) 1997; 272
T Ma (BFaps201127_CR31) 1997; 100
A Frigeri (BFaps201127_CR4) 1995; 108
DM Landis (BFaps201127_CR17) 1974; 60
O Bloch (BFaps201127_CR46) 2005; 95
P Padmawar (BFaps201127_CR63) 2005; 2
Z Zador (BFaps201127_CR66) 2008; 22
H Hasegawa (BFaps201127_CR1) 1994; 269
CS Furman (BFaps201127_CR25) 2003; 100
Z Li (BFaps201127_CR36) 2006; 403
M Tajima (BFaps201127_CR30) 2010; 285
MC Papadopoulos (BFaps201127_CR56) 2008; 456
J Badaut (BFaps201127_CR42) 2011; 31
B Yang (BFaps201127_CR44) 2008; 283
JM Crane (BFaps201127_CR83) 2011; 286
MJ Tait (BFaps201127_CR47) 2010; 167
S Saadoun (BFaps201127_CR34) 2009; 161
J Ruiz-Ederra (BFaps201127_CR70) 2007; 282
Andrea Rossi (BFaps201127_CR9) 2011; 59
X Yao (BFaps201127_CR65) 2008; 28
KI Auguste (BFaps201127_CR53) 2007; 21
M Lu (BFaps201127_CR6) 1996; 93
J Hu (BFaps201127_CR55) 2006; 20
J Li (BFaps201127_CR59) 2002; 43
M Bradl (BFaps201127_CR77) 2009; 66
Y Hiroaki (BFaps201127_CR22) 2006; 355
JS Hub (BFaps201127_CR15) 2009; 190
C Silberstein (BFaps201127_CR23) 2004; 287
EA Nagelhus (BFaps201127_CR69) 2004; 129
20713014 - Biophys J. 2010 Aug 9;99(4):1284-91
18267965 - Brain. 2008 Apr;131(Pt 4):1087-98
7509789 - J Biol Chem. 1994 Feb 25;269(8):5497-500
9751776 - Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11981-6
18973795 - Neurosci Lett. 2008 Dec 26;448(2):221-5
15695511 - J Biol Chem. 2005 Apr 8;280(14):13906-12
21257712 - FASEB J. 2011 May;25(5):1556-66
14597700 - Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13609-14
16181429 - J Neurochem. 2005 Oct;95(1):254-62
9276712 - J Clin Invest. 1997 Sep 1;100(5):957-62
20132873 - Neuroscience. 2010 Apr 28;167(1):60-7
15561407 - Neuroscience. 2004;129(4):905-13
16278651 - Nat Methods. 2005 Nov;2(11):825-7
7528931 - Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):13052-6
10460172 - Biochemistry. 1999 Aug 24;38(34):11156-63
18281883 - Neuroreport. 2008 Jan 8;19(1):1-5
18311471 - J Mol Med (Berl). 2008 May;86(5):523-9
4831157 - Exp Cell Res. 1974 May;86(1):187-90
16470808 - Glia. 2006 Apr 15;53(6):631-6
9427293 - J Cell Sci. 1997 Nov;110 ( Pt 22):2855-60
21262839 - Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2563-8
16717206 - Neurology. 2006 May 23;66(10):1485-9
17525153 - J Biol Chem. 2007 Jul 27;282(30):21866-72
20047900 - Brain. 2010 Feb;133(Pt 2):349-61
20071343 - J Biol Chem. 2010 Mar 12;285(11):8163-70
19938104 - Ann Neurol. 2009 Nov;66(5):617-29
21491501 - Glia. 2011 Jul;59(7):1056-63
10655103 - Nat Med. 2000 Feb;6(2):159-63
18495865 - Mol Biol Cell. 2008 Aug;19(8):3369-78
12824287 - FASEB J. 2003 Aug;17(11):1508-10
16797122 - Neurosci Lett. 2006 Aug 7;403(3):294-8
16087714 - J Exp Med. 2005 Aug 15;202(4):473-7
20463974 - PLoS One. 2010;5(5):e10455
20517941 - Ann Neurol. 2010 Jun;67(6):794-801
17706564 - Lancet Neurol. 2007 Sep;6(9):805-15
4809245 - J Cell Biol. 1974 Jan;60(1):316-20
17968585 - Pflugers Arch. 2008 Jul;456(4):693-700
16325200 - J Mol Biol. 2006 Jan 27;355(4):628-39
15149973 - Am J Physiol Renal Physiol. 2004 Sep;287(3):F501-11
9200715 - Biochemistry. 1997 Jun 17;36(24):7625-32
19096771 - Handb Exp Pharmacol. 2009;(190):31-56
19843522 - J Biol Chem. 2009 Dec 18;284(51):35850-60
9195910 - J Biol Chem. 1997 Jun 27;272(26):16140-6
11406631 - J Biol Chem. 2001 Aug 17;276(33):31233-7
18375385 - J Biol Chem. 2008 May 30;283(22):15280-6
16818469 - FASEB J. 2006 Sep;20(11):1892-4
19383790 - Proc Natl Acad Sci U S A. 2009 May 5;106(18):7437-42
17928579 - Neurology. 2007 Dec 11;69(24):2221-31
20877385 - J Cereb Blood Flow Metab. 2011 Mar;31(3):819-31
17965267 - FASEB J. 2008 Mar;22(3):870-9
15815633 - Nature. 2005 Apr 7;434(7034):786-92
21281561 - Int J Neuropsychopharmacol. 2012 Feb;15(1):55-68
11818406 - Invest Ophthalmol Vis Sci. 2002 Feb;43(2):573-9
15208268 - FASEB J. 2004 Aug;18(11):1291-3
8537439 - J Cell Sci. 1995 Sep;108 ( Pt 9):2993-3002
16552421 - J Cereb Blood Flow Metab. 2006 Dec;26(12):1527-37
17869537 - Mol Cell Neurosci. 2008 Jan;37(1):1-10
19948131 - Biophys J. 2009 Dec 2;97(11):3010-8
8855281 - Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10908-12
19660138 - BMC Neurosci. 2009;10:94
18255256 - Genomics. 2008 Apr;91(4):367-77
8617713 - J Biol Chem. 1996 Mar 1;271(9):4577-80
19096772 - Handb Exp Pharmacol. 2009;(190):57-76
8987746 - J Neurosci. 1997 Jan 1;17(1):171-80
19545538 - Biochem Biophys Res Commun. 2009 Sep 4;386(4):623-7
18511552 - FASEB J. 2008 Sep;22(9):3216-23
19937948 - Ann Neurol. 2009 Nov;66(5):630-43
19240114 - J Cell Sci. 2009 Mar 15;122(Pt 6):813-21
14597704 - Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13615-20
17135365 - FASEB J. 2007 Jan;21(1):108-16
17890385 - Biophys J. 2008 Jan 15;94(2):702-13
15371505 - J Neurosci. 2004 Sep 15;24(37):8049-56
19345723 - Neuroscience. 2009 Jul 7;161(3):764-72
16303850 - J Cell Sci. 2005 Dec 15;118(Pt 24):5691-8
18495879 - J Neurosci. 2008 May 21;28(21):5460-4
14735117 - Nat Rev Neurosci. 2004 Feb;5(2):146-56
7559426 - J Biol Chem. 1995 Sep 29;270(39):22907-13
15902261 - Nature. 2005 May 19;435(7040):365-9
19347962 - Cell Motil Cytoskeleton. 2009 May;66(5):237-47
18838545 - J Exp Med. 2008 Oct 27;205(11):2473-81
21454592 - J Biol Chem. 2011 May 6;286(18):16516-24
7538665 - Proc Natl Acad Sci U S A. 1995 May 9;92(10):4328-31
19229993 - Glia. 2009 Oct;57(13):1363-73
References_xml – volume: 271
  start-page: 4577
  year: 1996
  end-page: 80
  ident: CR19
  article-title: The mercurial insensitive water channel (AQP-4) forms orthogonal arrays in stably transfected Chinese hamster ovary cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.271.9.4577
– volume: 287
  start-page: F501
  year: 2004
  end-page: 11
  ident: CR23
  article-title: Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.00439.2003
– volume: 60
  start-page: 316
  year: 1974
  end-page: 20
  ident: CR17
  article-title: Arrays of particles in freeze-fractured astrocytic membranes
  publication-title: J Cell Biol
  doi: 10.1083/jcb.60.1.316
– volume: 6
  start-page: 159
  year: 2000
  end-page: 63
  ident: CR32
  article-title: Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke
  publication-title: Nat Med
  doi: 10.1038/72256
– volume: 284
  start-page: 35850
  year: 2009
  end-page: 60
  ident: CR10
  article-title: Live cell analysis of aquaporin-4 m1/m23 interactions and regulated orthogonal array assembly in glial cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.071670
– volume: 167
  start-page: 60
  year: 2010
  end-page: 7
  ident: CR47
  article-title: Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.01.053
– volume: 91
  start-page: 367
  year: 2008
  end-page: 77
  ident: CR8
  article-title: New isoforms of rat Aquaporin-4
  publication-title: Genomics
  doi: 10.1016/j.ygeno.2007.12.003
– volume: 97
  start-page: 3010
  year: 2009
  end-page: 8
  ident: CR29
  article-title: Reversible, temperature-dependent supramolecular assembly of aquaporin-4 orthogonal arrays in live cell membranes
  publication-title: Biophys J
  doi: 10.1016/j.bpj.2009.09.017
– volume: 36
  start-page: 7625
  year: 1997
  end-page: 32
  ident: CR12
  article-title: Very high single channel water permeability of aquaporin-4 in baculovirus-infected insect cells and liposomes reconstituted with purified aquaporin-4
  publication-title: Biochemistry (Mosc)
  doi: 10.1021/bi970231r
– volume: 20
  start-page: 1892
  year: 2006
  end-page: 4
  ident: CR55
  article-title: Increased migration and metastatic potential of tumor cells expressing aquaporin water channels
  publication-title: FASEB J
  doi: 10.1096/fj.06-5930fje
– volume: 6
  start-page: 805
  year: 2007
  end-page: 15
  ident: CR73
  article-title: The spectrum of neuromyelitis optica
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(07)70216-8
– volume: 21
  start-page: 108
  year: 2007
  end-page: 16
  ident: CR53
  article-title: Greatly impaired migration of implanted aquaporin-4-deficient astroglial cells in mouse brain toward a site of injury
  publication-title: FASEB J
  doi: 10.1096/fj.06-6848com
– volume: 94
  start-page: 702
  year: 2008
  end-page: 13
  ident: CR26
  article-title: Long-range nonanomalous diffusion of quantum dot-labeled aquaporin-1 water channels in the cell plasma membrane
  publication-title: Biophys J
  doi: 10.1529/biophysj.107.115121
– volume: 19
  start-page: 1
  year: 2008
  end-page: 5
  ident: CR35
  article-title: Altered blood-brain barrier integrity in adult aquaporin-4 knockout mice
  publication-title: Neuroreport
  doi: 10.1097/WNR.0b013e3282f2b4eb
– volume: 272
  start-page: 16140
  year: 1997
  end-page: 6
  ident: CR13
  article-title: Water and glycerol permeabilities of aquaporins 1–5 and MIP determined quantitatively by expression of epitope-tagged constructs in oocytes
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.26.16140
– volume: 86
  start-page: 187
  year: 1974
  end-page: 90
  ident: CR18
  article-title: Rectangular arrays of particles on freeze-cleaved plasma membranes are not gap junctions
  publication-title: Exp Cell Res
  doi: 10.1016/0014-4827(74)90670-3
– volume: 26
  start-page: 1527
  year: 2006
  end-page: 37
  ident: CR48
  article-title: Accelerated progression of kaolin-induced hydrocephalus in aquaporin-4-deficient mice
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/sj.jcbfm.9600306
– volume: 18
  start-page: 1291
  year: 2004
  end-page: 3
  ident: CR33
  article-title: Aquaporin-4 facilitates reabsorption of excess fluid in vasogenic brain edema
  publication-title: FASEB J
  doi: 10.1096/fj.04-1723fje
– volume: 25
  start-page: 1556
  year: 2011
  end-page: 66
  ident: CR40
  article-title: Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation
  publication-title: FASEB J
  doi: 10.1096/fj.10-177279
– volume: 57
  start-page: 1363
  year: 2009
  end-page: 73
  ident: CR24
  article-title: Aquaporin-4 orthogonal arrays of particles are the target for neuromyelitis optica autoantibodies
  publication-title: Glia
  doi: 10.1002/glia.20855
– volume: 110
  start-page: 2855
  year: 1997
  end-page: 60
  ident: CR20
  article-title: Absence of orthogonal arrays in kidney, brain and muscle from transgenic knockout mice lacking water channel aquaporin-4
  publication-title: J Cell Sci
  doi: 10.1242/jcs.110.22.2855
– volume: 86
  start-page: 523
  year: 2008
  end-page: 9
  ident: CR54
  article-title: Aquaporins — new players in cancer biology
  publication-title: J Mol Med
  doi: 10.1007/s00109-008-0303-9
– volume: 17
  start-page: 171
  year: 1997
  end-page: 80
  ident: CR5
  article-title: Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.17-01-00171.1997
– volume: 270
  start-page: 22907
  year: 1995
  end-page: 13
  ident: CR7
  article-title: cDNA cloning, gene organization, and chromosomal localization of a human mercurial insensitive water channel. Evidence for distinct transcriptional units
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.39.22907
– volume: 91
  start-page: 13052
  year: 1994
  end-page: 6
  ident: CR2
  article-title: Molecular characterization of an aquaporin cDNA from brain: candidate osmoreceptor and regulator of water balance
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.91.26.13052
– volume: 286
  start-page: 16516
  year: 2011
  end-page: 24
  ident: CR83
  article-title: Binding affinity and specificity of neuromyelitis optica autoantibodies to aquaporin-4 M1/M23 isoforms and orthogonal arrays
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.227298
– volume: 2
  start-page: 825
  year: 2005
  end-page: 7
  ident: CR63
  article-title: K waves in brain cortex visualized using a long-wavelength K -sensing fluorescent indicator
  publication-title: Nat Methods
  doi: 10.1038/nmeth801
– volume: 95
  start-page: 11981
  year: 1998
  end-page: 6
  ident: CR21
  article-title: Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.95.20.11981
– volume: 435
  start-page: 365
  year: 2005
  end-page: 9
  ident: CR58
  article-title: Non-equilibration of hydrostatic pressure in blebbing cells
  publication-title: Nature
  doi: 10.1038/nature03550
– volume: 129
  start-page: 905
  year: 2004
  end-page: 13
  ident: CR69
  article-title: Aquaporin-4 in the central nervous system: cellular and subcellular distribution and coexpression with KIR4.1
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2004.08.053
– volume: 66
  start-page: 617
  year: 2009
  end-page: 29
  ident: CR76
  article-title: Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica
  publication-title: Ann Neurol
  doi: 10.1002/ana.21802
– volume: 17
  start-page: 1508
  year: 2003
  end-page: 10
  ident: CR39
  article-title: Inhibition of aquaporin-4 expression in astrocytes by RNAi determines alteration in cell morphology, growth, and water transport and induces changes in ischemia-related genes
  publication-title: FASEB J
  doi: 10.1096/fj.02-1183fje
– volume: 99
  start-page: 1284
  year: 2010
  end-page: 91
  ident: CR67
  article-title: Microfiberoptic measurement of extracellular space volume in brain and tumor slices based on fluorescent dye partitioning
  publication-title: Biophys J
  doi: 10.1016/j.bpj.2010.06.023
– volume: 19
  start-page: 3369
  year: 2008
  end-page: 78
  ident: CR27
  article-title: Aquaporin-4 dynamics in orthogonal arrays in live cells visualized by quantum dot single particle tracking
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e08-03-0322
– volume: 133
  start-page: 349
  year: 2010
  end-page: 61
  ident: CR79
  article-title: Intra-cerebral injection of neuromyelitis optica immunoglobulin G and human complement produces neuromyelitis optica lesions in mice
  publication-title: Brain
  doi: 10.1093/brain/awp309
– volume: 93
  start-page: 10908
  year: 1996
  end-page: 12
  ident: CR6
  article-title: The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.93.20.10908
– volume: 100
  start-page: 957
  year: 1997
  end-page: 62
  ident: CR31
  article-title: Generation and phenotype of a transgenic knockout mouse lacking the mercurial-insensitive water channel aquaporin-4
  publication-title: J Clin Invest
  doi: 10.1172/JCI231
– volume: 106
  start-page: 7437
  year: 2009
  end-page: 42
  ident: CR14
  article-title: Crystal structure of human aquaporin 4 at 1.8 A and its mechanism of conductance
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0902725106
– volume: 403
  start-page: 294
  year: 2006
  end-page: 8
  ident: CR36
  article-title: Aquaporin-4 knockout regulated cocaine-induced behavior and neurochemical changes in mice
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2006.05.004
– volume: 161
  start-page: 764
  year: 2009
  end-page: 72
  ident: CR34
  article-title: AQP4 gene deletion in mice does not alter blood-brain barrier integrity or brain morphology
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2009.03.069
– volume: 100
  start-page: 13615
  year: 2003
  end-page: 20
  ident: CR68
  article-title: Delayed K clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2336064100
– volume: 53
  start-page: 631
  year: 2006
  end-page: 6
  ident: CR62
  article-title: Increased seizure duration and slowed potassium kinetics in mice lacking aquaporin-4 water channels
  publication-title: Glia
  doi: 10.1002/glia.20318
– volume: 122
  start-page: 813
  year: 2009
  end-page: 21
  ident: CR28
  article-title: Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging
  publication-title: J Cell Sci
  doi: 10.1242/jcs.042341
– volume: 448
  start-page: 221
  year: 2008
  end-page: 5
  ident: CR38
  article-title: Aquaporin 4 deficiency modulates morphine pharmacological actions
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.10.065
– volume: 24
  start-page: 8049
  year: 2004
  end-page: 56
  ident: CR64
  article-title: measurement of brain extracellular space diffusion by cortical surface photobleaching
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2294-04.2004
– volume: 95
  start-page: 254
  year: 2005
  end-page: 62
  ident: CR46
  article-title: Aquaporin-4 gene deletion in mice increases focal edema associated with staphylococcal brain abscess
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2005.03362.x
– volume: 66
  start-page: 630
  year: 2009
  end-page: 43
  ident: CR77
  article-title: Neuromyelitis optica: pathogenicity of patient immunoglobulin
  publication-title: Ann Neurol
  doi: 10.1002/ana.21837
– volume: 59
  start-page: 1056
  issue: 7
  year: 2011
  end-page: 1063
  ident: CR9
  article-title: Aquaporin-4 Mz isoform: Brain expression, supramolecular assembly and neuromyelitis optica antibody binding
  publication-title: Glia
  doi: 10.1002/glia.21177
– volume: 276
  start-page: 31233
  year: 2001
  end-page: 7
  ident: CR60
  article-title: Impaired hearing in mice lacking aquaporin-4 water channels
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M104368200
– volume: 131
  start-page: 1087
  year: 2008
  end-page: 98
  ident: CR49
  article-title: Greatly improved neurological outcome after spinal cord compression injury in AQP4-deficient mice
  publication-title: Brain
  doi: 10.1093/brain/awn014
– volume: 280
  start-page: 13906
  year: 2005
  end-page: 12
  ident: CR43
  article-title: Aquaporin-4 gene disruption in mice reduces brain swelling and mortality in pneumococcal meningitis
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M413627200
– volume: 118
  start-page: 5691
  year: 2005
  end-page: 8
  ident: CR41
  article-title: Involvement of aquaporin-4 in astroglial cell migration and glial scar formation
  publication-title: J Cell Sci
  doi: 10.1242/jcs.02680
– volume: 28
  start-page: 5460
  year: 2008
  end-page: 4
  ident: CR65
  article-title: Aquaporin-4-deficient mice have increased extracellular space without tortuosity change
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0257-08.2008
– volume: 456
  start-page: 693
  year: 2008
  end-page: 700
  ident: CR56
  article-title: Aquaporins and cell migration
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-007-0357-5
– volume: 69
  start-page: 2221
  year: 2007
  end-page: 31
  ident: CR80
  article-title: Pathogenic potential of IgG binding to water channel extracellular domain in neuromyelitis optica
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000289761.64862.ce
– volume: 190
  start-page: 57
  year: 2009
  end-page: 76
  ident: CR15
  article-title: Dynamics and energetics of permeation through aquaporins. What do we learn from molecular dynamics simulations?
  publication-title: Handb Exp Pharmacol
  doi: 10.1007/978-3-540-79885-9_3
– volume: 15
  start-page: 55
  issue: 01
  year: 2011
  end-page: 68
  ident: CR37
  article-title: Aquaporin-4 deficiency exacerbates brain oxidative damage and memory deficits induced by long-term ovarian hormone deprivation and D-galactose injection
  publication-title: The International Journal of Neuropsychopharmacology
  doi: 10.1017/S1461145711000022
– volume: 108
  start-page: 2563
  year: 2011
  end-page: 8
  ident: CR45
  article-title: An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1012867108
– volume: 38
  start-page: 11156
  year: 1999
  end-page: 63
  ident: CR11
  article-title: Heterotetrameric composition of aquaporin-4 water channels
  publication-title: Biochemistry (Mosc)
  doi: 10.1021/bi990941s
– volume: 92
  start-page: 4328
  year: 1995
  end-page: 31
  ident: CR3
  article-title: Immunolocalization of the mercurial-insensitive water channel and glycerol intrinsic protein in epithelial cell plasma membranes
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.92.10.4328
– volume: 22
  start-page: 3216
  year: 2008
  end-page: 23
  ident: CR61
  article-title: Impaired olfaction in mice lacking aquaporin-4 water channels
  publication-title: FASEB J
  doi: 10.1096/fj.07-104836
– volume: 67
  start-page: 794
  year: 2010
  end-page: 801
  ident: CR50
  article-title: Protective role of aquaporin-4 water channels after contusion spinal cord injury
  publication-title: Ann Neurol
– volume: 355
  start-page: 628
  year: 2006
  end-page: 39
  ident: CR22
  article-title: Implications of the aquaporin-4 structure on array formation and cell adhesion
  publication-title: J Mol Biol
  doi: 10.1016/j.jmb.2005.10.081
– volume: 66
  start-page: 1485
  year: 2006
  end-page: 9
  ident: CR82
  article-title: Revised diagnostic criteria for neuromyelitis optica
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000216139.44259.74
– volume: 285
  start-page: 8163
  year: 2010
  end-page: 70
  ident: CR30
  article-title: Aquaporin-4 (AQP4) associations and array dynamics probed by photobleaching and single-molecule analysis of green fluorescent protein-AQP4 chimeras
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.093948
– volume: 31
  start-page: 819
  year: 2011
  end-page: 31
  ident: CR42
  article-title: Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interference
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2010.163
– volume: 283
  start-page: 15280
  year: 2008
  end-page: 6
  ident: CR44
  article-title: Glial cell aquaporin-4 overexpression in transgenic mice accelerates cytotoxic brain swelling
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M801425200
– volume: 202
  start-page: 473
  year: 2005
  end-page: 7
  ident: CR74
  article-title: IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel
  publication-title: J Exp Med
  doi: 10.1084/jem.20050304
– volume: 282
  start-page: 21866
  year: 2007
  end-page: 72
  ident: CR70
  article-title: Evidence against functional interaction between aquaporin-4 water channels and Kir4.1 potassium channels in retinal Muller cells
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M703236200
– volume: 37
  start-page: 1
  year: 2008
  end-page: 10
  ident: CR71
  article-title: Aquaporin-4 independent Kir4.1 K channel function in brain glial cells
  publication-title: Mol Cell Neurosci
  doi: 10.1016/j.mcn.2007.08.007
– volume: 100
  start-page: 13609
  year: 2003
  end-page: 14
  ident: CR25
  article-title: Aquaporin-4 square array assembly: opposing actions of M1 and M23 isoforms
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2235843100
– volume: 269
  start-page: 5497
  year: 1994
  end-page: 500
  ident: CR1
  article-title: Molecular cloning of a mercurial-insensitive water channel expressed in selected water-transporting tissues
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(17)37486-0
– volume: 190
  start-page: 31
  year: 2009
  end-page: 56
  ident: CR16
  article-title: The AQP structure and functional implications
  publication-title: Handb Exp Pharmacol
  doi: 10.1007/978-3-540-79885-9_2
– volume: 66
  start-page: 237
  year: 2009
  end-page: 47
  ident: CR57
  article-title: Water flux in cell motility: expanding the mechanisms of membrane protrusion
  publication-title: Cell Motil Cytoskeleton
  doi: 10.1002/cm.20357
– volume: 434
  start-page: 786
  year: 2005
  end-page: 92
  ident: CR51
  article-title: Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
  publication-title: Nature
  doi: 10.1038/nature03460
– volume: 10
  start-page: 94
  year: 2009
  ident: CR72
  article-title: Greatly attenuated experimental autoimmune encephalomyelitis in aquaporin-4 knockout mice
  publication-title: BMC Neurosci
  doi: 10.1186/1471-2202-10-94
– volume: 22
  start-page: 870
  year: 2008
  end-page: 9
  ident: CR66
  article-title: Microfiberoptic fluorescence photobleaching reveals size-dependent macromolecule diffusion in extracellular space deep in brain
  publication-title: FASEB J
  doi: 10.1096/fj.07-9468com
– volume: 5
  start-page: 146
  year: 2004
  end-page: 56
  ident: CR52
  article-title: Regeneration beyond the glial scar
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn1326
– volume: 5
  start-page: e10455
  year: 2010
  ident: CR75
  article-title: Patterns of antibody binding to aquaporin-4 isoforms in neuromyelitis optica
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0010455
– volume: 386
  start-page: 623
  year: 2009
  end-page: 7
  ident: CR78
  article-title: Neuromyelitis optica: Passive transfer to rats by human immunoglobulin
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2009.06.085
– volume: 205
  start-page: 2473
  year: 2008
  end-page: 81
  ident: CR81
  article-title: Aquaporin-4-binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2
  publication-title: J Exp Med
  doi: 10.1084/jem.20081241
– volume: 108
  start-page: 2993
  year: 1995
  end-page: 3002
  ident: CR4
  article-title: Localization of MIWC and GLIP water channel homologs in neuromuscular, epithelial and glandular tissues
  publication-title: J Cell Sci
  doi: 10.1242/jcs.108.9.2993
– volume: 43
  start-page: 573
  year: 2002
  end-page: 9
  ident: CR59
  article-title: Mildly abnormal retinal function in transgenic mice without Muller cell aquaporin-4 water channels
  publication-title: Invest Ophthalmol Vis Sci
– volume: 86
  start-page: 523
  year: 2008
  ident: BFaps201127_CR54
  publication-title: J Mol Med
  doi: 10.1007/s00109-008-0303-9
– volume: 118
  start-page: 5691
  year: 2005
  ident: BFaps201127_CR41
  publication-title: J Cell Sci
  doi: 10.1242/jcs.02680
– volume: 100
  start-page: 13615
  year: 2003
  ident: BFaps201127_CR68
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2336064100
– volume: 17
  start-page: 171
  year: 1997
  ident: BFaps201127_CR5
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.17-01-00171.1997
– volume: 270
  start-page: 22907
  year: 1995
  ident: BFaps201127_CR7
  publication-title: J Biol Chem
  doi: 10.1074/jbc.270.39.22907
– volume: 355
  start-page: 628
  year: 2006
  ident: BFaps201127_CR22
  publication-title: J Mol Biol
  doi: 10.1016/j.jmb.2005.10.081
– volume: 285
  start-page: 8163
  year: 2010
  ident: BFaps201127_CR30
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.093948
– volume: 283
  start-page: 15280
  year: 2008
  ident: BFaps201127_CR44
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M801425200
– volume: 38
  start-page: 11156
  year: 1999
  ident: BFaps201127_CR11
  publication-title: Biochemistry (Mosc)
  doi: 10.1021/bi990941s
– volume: 17
  start-page: 1508
  year: 2003
  ident: BFaps201127_CR39
  publication-title: FASEB J
  doi: 10.1096/fj.02-1183fje
– volume: 66
  start-page: 617
  year: 2009
  ident: BFaps201127_CR76
  publication-title: Ann Neurol
  doi: 10.1002/ana.21802
– volume: 94
  start-page: 702
  year: 2008
  ident: BFaps201127_CR26
  publication-title: Biophys J
  doi: 10.1529/biophysj.107.115121
– volume: 26
  start-page: 1527
  year: 2006
  ident: BFaps201127_CR48
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/sj.jcbfm.9600306
– volume: 106
  start-page: 7437
  year: 2009
  ident: BFaps201127_CR14
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.0902725106
– volume: 86
  start-page: 187
  year: 1974
  ident: BFaps201127_CR18
  publication-title: Exp Cell Res
  doi: 10.1016/0014-4827(74)90670-3
– volume: 24
  start-page: 8049
  year: 2004
  ident: BFaps201127_CR64
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2294-04.2004
– volume: 22
  start-page: 3216
  year: 2008
  ident: BFaps201127_CR61
  publication-title: FASEB J
  doi: 10.1096/fj.07-104836
– volume: 95
  start-page: 11981
  year: 1998
  ident: BFaps201127_CR21
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.95.20.11981
– volume: 456
  start-page: 693
  year: 2008
  ident: BFaps201127_CR56
  publication-title: Pflugers Arch
  doi: 10.1007/s00424-007-0357-5
– volume: 66
  start-page: 1485
  year: 2006
  ident: BFaps201127_CR82
  publication-title: Neurology
  doi: 10.1212/01.wnl.0000216139.44259.74
– volume: 167
  start-page: 60
  year: 2010
  ident: BFaps201127_CR47
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2010.01.053
– volume: 287
  start-page: F501
  year: 2004
  ident: BFaps201127_CR23
  publication-title: Am J Physiol Renal Physiol
  doi: 10.1152/ajprenal.00439.2003
– volume: 97
  start-page: 3010
  year: 2009
  ident: BFaps201127_CR29
  publication-title: Biophys J
  doi: 10.1016/j.bpj.2009.09.017
– volume: 53
  start-page: 631
  year: 2006
  ident: BFaps201127_CR62
  publication-title: Glia
  doi: 10.1002/glia.20318
– volume: 205
  start-page: 2473
  year: 2008
  ident: BFaps201127_CR81
  publication-title: J Exp Med
  doi: 10.1084/jem.20081241
– volume: 36
  start-page: 7625
  year: 1997
  ident: BFaps201127_CR12
  publication-title: Biochemistry (Mosc)
  doi: 10.1021/bi970231r
– volume: 25
  start-page: 1556
  year: 2011
  ident: BFaps201127_CR40
  publication-title: FASEB J
  doi: 10.1096/fj.10-177279
– volume: 95
  start-page: 254
  year: 2005
  ident: BFaps201127_CR46
  publication-title: J Neurochem
  doi: 10.1111/j.1471-4159.2005.03362.x
– volume: 403
  start-page: 294
  year: 2006
  ident: BFaps201127_CR36
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2006.05.004
– volume: 386
  start-page: 623
  year: 2009
  ident: BFaps201127_CR78
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2009.06.085
– volume: 110
  start-page: 2855
  year: 1997
  ident: BFaps201127_CR20
  publication-title: J Cell Sci
  doi: 10.1242/jcs.110.22.2855
– volume: 276
  start-page: 31233
  year: 2001
  ident: BFaps201127_CR60
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M104368200
– volume: 37
  start-page: 1
  year: 2008
  ident: BFaps201127_CR71
  publication-title: Mol Cell Neurosci
  doi: 10.1016/j.mcn.2007.08.007
– volume: 67
  start-page: 794
  year: 2010
  ident: BFaps201127_CR50
  publication-title: Ann Neurol
  doi: 10.1002/ana.22023
– volume: 133
  start-page: 349
  year: 2010
  ident: BFaps201127_CR79
  publication-title: Brain
  doi: 10.1093/brain/awp309
– volume: 5
  start-page: 146
  year: 2004
  ident: BFaps201127_CR52
  publication-title: Nat Rev Neurosci
  doi: 10.1038/nrn1326
– volume: 91
  start-page: 13052
  year: 1994
  ident: BFaps201127_CR2
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.91.26.13052
– volume: 269
  start-page: 5497
  year: 1994
  ident: BFaps201127_CR1
  publication-title: J Biol Chem
  doi: 10.1016/S0021-9258(17)37486-0
– volume: 18
  start-page: 1291
  year: 2004
  ident: BFaps201127_CR33
  publication-title: FASEB J
  doi: 10.1096/fj.04-1723fje
– volume: 31
  start-page: 819
  year: 2011
  ident: BFaps201127_CR42
  publication-title: J Cereb Blood Flow Metab
  doi: 10.1038/jcbfm.2010.163
– volume: 5
  start-page: e10455
  year: 2010
  ident: BFaps201127_CR75
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0010455
– volume: 93
  start-page: 10908
  year: 1996
  ident: BFaps201127_CR6
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.93.20.10908
– volume: 66
  start-page: 630
  year: 2009
  ident: BFaps201127_CR77
  publication-title: Ann Neurol
  doi: 10.1002/ana.21837
– volume: 100
  start-page: 13609
  year: 2003
  ident: BFaps201127_CR25
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.2235843100
– volume: 190
  start-page: 31
  year: 2009
  ident: BFaps201127_CR16
  publication-title: Handb Exp Pharmacol
  doi: 10.1007/978-3-540-79885-9_2
– volume: 15
  start-page: 55
  issue: 01
  year: 2011
  ident: BFaps201127_CR37
  publication-title: The International Journal of Neuropsychopharmacology
  doi: 10.1017/S1461145711000022
– volume: 69
  start-page: 2221
  year: 2007
  ident: BFaps201127_CR80
  publication-title: Neurology
  doi: 10.1212/01.WNL.0000289761.64862.ce
– volume: 6
  start-page: 159
  year: 2000
  ident: BFaps201127_CR32
  publication-title: Nat Med
  doi: 10.1038/72256
– volume: 108
  start-page: 2563
  year: 2011
  ident: BFaps201127_CR45
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1012867108
– volume: 282
  start-page: 21866
  year: 2007
  ident: BFaps201127_CR70
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M703236200
– volume: 161
  start-page: 764
  year: 2009
  ident: BFaps201127_CR34
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2009.03.069
– volume: 10
  start-page: 94
  year: 2009
  ident: BFaps201127_CR72
  publication-title: BMC Neurosci
  doi: 10.1186/1471-2202-10-94
– volume: 22
  start-page: 870
  year: 2008
  ident: BFaps201127_CR66
  publication-title: FASEB J
  doi: 10.1096/fj.07-9468com
– volume: 57
  start-page: 1363
  year: 2009
  ident: BFaps201127_CR24
  publication-title: Glia
  doi: 10.1002/glia.20855
– volume: 66
  start-page: 237
  year: 2009
  ident: BFaps201127_CR57
  publication-title: Cell Motil Cytoskeleton
  doi: 10.1002/cm.20357
– volume: 2
  start-page: 825
  year: 2005
  ident: BFaps201127_CR63
  publication-title: Nat Methods
  doi: 10.1038/nmeth801
– volume: 100
  start-page: 957
  year: 1997
  ident: BFaps201127_CR31
  publication-title: J Clin Invest
  doi: 10.1172/JCI231
– volume: 20
  start-page: 1892
  year: 2006
  ident: BFaps201127_CR55
  publication-title: FASEB J
  doi: 10.1096/fj.06-5930fje
– volume: 92
  start-page: 4328
  year: 1995
  ident: BFaps201127_CR3
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.92.10.4328
– volume: 284
  start-page: 35850
  year: 2009
  ident: BFaps201127_CR10
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M109.071670
– volume: 272
  start-page: 16140
  year: 1997
  ident: BFaps201127_CR13
  publication-title: J Biol Chem
  doi: 10.1074/jbc.272.26.16140
– volume: 59
  start-page: 1056
  issue: 7
  year: 2011
  ident: BFaps201127_CR9
  publication-title: Glia
  doi: 10.1002/glia.21177
– volume: 190
  start-page: 57
  year: 2009
  ident: BFaps201127_CR15
  publication-title: Handb Exp Pharmacol
  doi: 10.1007/978-3-540-79885-9_3
– volume: 202
  start-page: 473
  year: 2005
  ident: BFaps201127_CR74
  publication-title: J Exp Med
  doi: 10.1084/jem.20050304
– volume: 28
  start-page: 5460
  year: 2008
  ident: BFaps201127_CR65
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.0257-08.2008
– volume: 448
  start-page: 221
  year: 2008
  ident: BFaps201127_CR38
  publication-title: Neurosci Lett
  doi: 10.1016/j.neulet.2008.10.065
– volume: 435
  start-page: 365
  year: 2005
  ident: BFaps201127_CR58
  publication-title: Nature
  doi: 10.1038/nature03550
– volume: 99
  start-page: 1284
  year: 2010
  ident: BFaps201127_CR67
  publication-title: Biophys J
  doi: 10.1016/j.bpj.2010.06.023
– volume: 280
  start-page: 13906
  year: 2005
  ident: BFaps201127_CR43
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M413627200
– volume: 6
  start-page: 805
  year: 2007
  ident: BFaps201127_CR73
  publication-title: Lancet Neurol
  doi: 10.1016/S1474-4422(07)70216-8
– volume: 131
  start-page: 1087
  year: 2008
  ident: BFaps201127_CR49
  publication-title: Brain
  doi: 10.1093/brain/awn014
– volume: 129
  start-page: 905
  year: 2004
  ident: BFaps201127_CR69
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2004.08.053
– volume: 286
  start-page: 16516
  year: 2011
  ident: BFaps201127_CR83
  publication-title: J Biol Chem
  doi: 10.1074/jbc.M111.227298
– volume: 108
  start-page: 2993
  year: 1995
  ident: BFaps201127_CR4
  publication-title: J Cell Sci
  doi: 10.1242/jcs.108.9.2993
– volume: 434
  start-page: 786
  year: 2005
  ident: BFaps201127_CR51
  publication-title: Nature
  doi: 10.1038/nature03460
– volume: 271
  start-page: 4577
  year: 1996
  ident: BFaps201127_CR19
  publication-title: J Biol Chem
  doi: 10.1074/jbc.271.9.4577
– volume: 19
  start-page: 3369
  year: 2008
  ident: BFaps201127_CR27
  publication-title: Mol Biol Cell
  doi: 10.1091/mbc.e08-03-0322
– volume: 19
  start-page: 1
  year: 2008
  ident: BFaps201127_CR35
  publication-title: Neuroreport
  doi: 10.1097/WNR.0b013e3282f2b4eb
– volume: 21
  start-page: 108
  year: 2007
  ident: BFaps201127_CR53
  publication-title: FASEB J
  doi: 10.1096/fj.06-6848com
– volume: 43
  start-page: 573
  year: 2002
  ident: BFaps201127_CR59
  publication-title: Invest Ophthalmol Vis Sci
– volume: 91
  start-page: 367
  year: 2008
  ident: BFaps201127_CR8
  publication-title: Genomics
  doi: 10.1016/j.ygeno.2007.12.003
– volume: 122
  start-page: 813
  year: 2009
  ident: BFaps201127_CR28
  publication-title: J Cell Sci
  doi: 10.1242/jcs.042341
– volume: 60
  start-page: 316
  year: 1974
  ident: BFaps201127_CR17
  publication-title: J Cell Biol
  doi: 10.1083/jcb.60.1.316
– reference: 17890385 - Biophys J. 2008 Jan 15;94(2):702-13
– reference: 9276712 - J Clin Invest. 1997 Sep 1;100(5):957-62
– reference: 18281883 - Neuroreport. 2008 Jan 8;19(1):1-5
– reference: 19347962 - Cell Motil Cytoskeleton. 2009 May;66(5):237-47
– reference: 17928579 - Neurology. 2007 Dec 11;69(24):2221-31
– reference: 20071343 - J Biol Chem. 2010 Mar 12;285(11):8163-70
– reference: 15815633 - Nature. 2005 Apr 7;434(7034):786-92
– reference: 12824287 - FASEB J. 2003 Aug;17(11):1508-10
– reference: 19545538 - Biochem Biophys Res Commun. 2009 Sep 4;386(4):623-7
– reference: 19948131 - Biophys J. 2009 Dec 2;97(11):3010-8
– reference: 20877385 - J Cereb Blood Flow Metab. 2011 Mar;31(3):819-31
– reference: 17706564 - Lancet Neurol. 2007 Sep;6(9):805-15
– reference: 15695511 - J Biol Chem. 2005 Apr 8;280(14):13906-12
– reference: 15149973 - Am J Physiol Renal Physiol. 2004 Sep;287(3):F501-11
– reference: 18267965 - Brain. 2008 Apr;131(Pt 4):1087-98
– reference: 17965267 - FASEB J. 2008 Mar;22(3):870-9
– reference: 10460172 - Biochemistry. 1999 Aug 24;38(34):11156-63
– reference: 18375385 - J Biol Chem. 2008 May 30;283(22):15280-6
– reference: 14597700 - Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13609-14
– reference: 19096771 - Handb Exp Pharmacol. 2009;(190):31-56
– reference: 9427293 - J Cell Sci. 1997 Nov;110 ( Pt 22):2855-60
– reference: 19240114 - J Cell Sci. 2009 Mar 15;122(Pt 6):813-21
– reference: 17135365 - FASEB J. 2007 Jan;21(1):108-16
– reference: 14597704 - Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13615-20
– reference: 20463974 - PLoS One. 2010;5(5):e10455
– reference: 11818406 - Invest Ophthalmol Vis Sci. 2002 Feb;43(2):573-9
– reference: 16717206 - Neurology. 2006 May 23;66(10):1485-9
– reference: 21454592 - J Biol Chem. 2011 May 6;286(18):16516-24
– reference: 20132873 - Neuroscience. 2010 Apr 28;167(1):60-7
– reference: 15371505 - J Neurosci. 2004 Sep 15;24(37):8049-56
– reference: 21257712 - FASEB J. 2011 May;25(5):1556-66
– reference: 8617713 - J Biol Chem. 1996 Mar 1;271(9):4577-80
– reference: 16303850 - J Cell Sci. 2005 Dec 15;118(Pt 24):5691-8
– reference: 7559426 - J Biol Chem. 1995 Sep 29;270(39):22907-13
– reference: 16818469 - FASEB J. 2006 Sep;20(11):1892-4
– reference: 17968585 - Pflugers Arch. 2008 Jul;456(4):693-700
– reference: 19096772 - Handb Exp Pharmacol. 2009;(190):57-76
– reference: 4831157 - Exp Cell Res. 1974 May;86(1):187-90
– reference: 21491501 - Glia. 2011 Jul;59(7):1056-63
– reference: 17525153 - J Biol Chem. 2007 Jul 27;282(30):21866-72
– reference: 17869537 - Mol Cell Neurosci. 2008 Jan;37(1):1-10
– reference: 16087714 - J Exp Med. 2005 Aug 15;202(4):473-7
– reference: 16470808 - Glia. 2006 Apr 15;53(6):631-6
– reference: 16552421 - J Cereb Blood Flow Metab. 2006 Dec;26(12):1527-37
– reference: 11406631 - J Biol Chem. 2001 Aug 17;276(33):31233-7
– reference: 16181429 - J Neurochem. 2005 Oct;95(1):254-62
– reference: 7509789 - J Biol Chem. 1994 Feb 25;269(8):5497-500
– reference: 8855281 - Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10908-12
– reference: 18255256 - Genomics. 2008 Apr;91(4):367-77
– reference: 16278651 - Nat Methods. 2005 Nov;2(11):825-7
– reference: 21281561 - Int J Neuropsychopharmacol. 2012 Feb;15(1):55-68
– reference: 19937948 - Ann Neurol. 2009 Nov;66(5):630-43
– reference: 19345723 - Neuroscience. 2009 Jul 7;161(3):764-72
– reference: 18838545 - J Exp Med. 2008 Oct 27;205(11):2473-81
– reference: 15208268 - FASEB J. 2004 Aug;18(11):1291-3
– reference: 19938104 - Ann Neurol. 2009 Nov;66(5):617-29
– reference: 18311471 - J Mol Med (Berl). 2008 May;86(5):523-9
– reference: 9195910 - J Biol Chem. 1997 Jun 27;272(26):16140-6
– reference: 19383790 - Proc Natl Acad Sci U S A. 2009 May 5;106(18):7437-42
– reference: 7528931 - Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):13052-6
– reference: 9751776 - Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11981-6
– reference: 4809245 - J Cell Biol. 1974 Jan;60(1):316-20
– reference: 18511552 - FASEB J. 2008 Sep;22(9):3216-23
– reference: 10655103 - Nat Med. 2000 Feb;6(2):159-63
– reference: 8987746 - J Neurosci. 1997 Jan 1;17(1):171-80
– reference: 19660138 - BMC Neurosci. 2009;10:94
– reference: 20713014 - Biophys J. 2010 Aug 9;99(4):1284-91
– reference: 19229993 - Glia. 2009 Oct;57(13):1363-73
– reference: 16797122 - Neurosci Lett. 2006 Aug 7;403(3):294-8
– reference: 20517941 - Ann Neurol. 2010 Jun;67(6):794-801
– reference: 15902261 - Nature. 2005 May 19;435(7040):365-9
– reference: 14735117 - Nat Rev Neurosci. 2004 Feb;5(2):146-56
– reference: 21262839 - Proc Natl Acad Sci U S A. 2011 Feb 8;108(6):2563-8
– reference: 18495879 - J Neurosci. 2008 May 21;28(21):5460-4
– reference: 8537439 - J Cell Sci. 1995 Sep;108 ( Pt 9):2993-3002
– reference: 20047900 - Brain. 2010 Feb;133(Pt 2):349-61
– reference: 18973795 - Neurosci Lett. 2008 Dec 26;448(2):221-5
– reference: 19843522 - J Biol Chem. 2009 Dec 18;284(51):35850-60
– reference: 15561407 - Neuroscience. 2004;129(4):905-13
– reference: 18495865 - Mol Biol Cell. 2008 Aug;19(8):3369-78
– reference: 7538665 - Proc Natl Acad Sci U S A. 1995 May 9;92(10):4328-31
– reference: 9200715 - Biochemistry. 1997 Jun 17;36(24):7625-32
– reference: 16325200 - J Mol Biol. 2006 Jan 27;355(4):628-39
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SecondaryResourceType review_article
Snippet Aquaporin-4 （AQP4） is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and...
Aquaporin-4 (AQP4) is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and...
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pubmed
crossref
springer
chongqing
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 702
SubjectTerms Amino Acid Sequence
Animals
Antibodies, Monoclonal - administration & dosage
Antibodies, Monoclonal - therapeutic use
Aquaporin 4
Aquaporin 4 - chemistry
Aquaporin 4 - immunology
Aquaporin 4 - physiology
Astrocytes
Autoantibodies
Biomedical and Life Sciences
Biomedicine
Brain
Brain injury
Cell migration
Central nervous system
Central Nervous System - immunology
Central Nervous System - metabolism
Central Nervous System - physiology
Demyelinating diseases
Drug Discovery
Edema
Glial fibrillary acidic protein
High-Throughput Screening Assays
Humans
Immunology
Immunoreactivity
Inflammation
Internal Medicine
Kidney
Lung
Medical Microbiology
Molecular Sequence Data
Neuromodulation
Neuromyelitis
Neuromyelitis Optica - drug therapy
Neuromyelitis Optica - immunology
Neuromyelitis Optica - metabolism
Neuronal-glial interactions
Permeability
Pharmacology/Toxicology
Plasma membranes
Protein Binding
Protein Multimerization
Review
Small Molecule Libraries - chemistry
Small Molecule Libraries - therapeutic use
Vaccine
中枢神经系统
星形胶质细胞
正交表
水通道蛋白4
神经胶质
胶质纤维酸性蛋白
自身免疫性
视神经
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Title Aquaporin-4： orthogonal array assembly, CNS functions, and role in neuromyelitis optica
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https://link.springer.com/article/10.1038/aps.2011.27
https://www.ncbi.nlm.nih.gov/pubmed/21552296
https://www.proquest.com/docview/873162844
https://www.proquest.com/docview/1028080681
https://www.proquest.com/docview/870546524
https://pubmed.ncbi.nlm.nih.gov/PMC3601948
Volume 32
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