Image-based modeling of hemodynamics in coronary artery aneurysms caused by Kawasaki disease

• Published in: Biomechanics and modeling in mechanobiology Vol. 11; no. 6; pp. 915 - 932
• Main Authors: Sengupta, Dibyendu, Kahn, Andrew M., Burns, Jane C., Sankaran, Sethuraman, Shadden, Shawn C., Marsden, Alison L.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.07.2012; Springer Nature B.V
• Subjects: Aneurysms; Biological and Medical Physics; Biomechanics; Biomedical Engineering and Bioengineering; Biophysics; Blood Flow Velocity - physiology; Blood Pressure - physiology; Boundary conditions; Cardiovascular diseases; Child; Child, Preschool; Computed tomography; Computer Simulation; Coronary Aneurysm - diagnostic imaging; Coronary Aneurysm - etiology; Coronary Aneurysm - physiopathology; Coronary Angiography; Coronary vessels; Coronary Vessels - physiopathology; Engineering; Hemodynamics - physiology; Humans; Imaging, Three-Dimensional - methods; Male; Models, Cardiovascular; Mucocutaneous Lymph Node Syndrome - complications; Myocardial infarction; Original Paper; Quantitative research; Shear stress; Stress, Mechanical; Theoretical and Applied Mechanics; Thromboembolism; Kawasaki disease; Wall shear stress; Residence time; Aneurysm

Kawasaki Disease (KD) is the leading cause of acquired pediatric heart disease. A subset of KD patients develops aneurysms in the coronary arteries, leading to increased risk of thrombosis and myocardial infarction. Currently, there are limited clinical data to guide the management of these patients...