Mesenchymal stem cells: therapeutic outlook for stroke
Adult bone marrow-derived mesenchymal stem cells (MSCs) display a spectrum of functional properties. Transplantation of these cells improves clinical outcome in models of cerebral ischemia and spinal cord injury via mechanisms that may include replacement of damaged cells, neuroprotective effects, i...
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| Published in | Trends in molecular medicine Vol. 18; no. 5; pp. 292 - 297 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.05.2012
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1471-4914 1471-499X 1471-499X |
| DOI | 10.1016/j.molmed.2012.02.003 |
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| Abstract | Adult bone marrow-derived mesenchymal stem cells (MSCs) display a spectrum of functional properties. Transplantation of these cells improves clinical outcome in models of cerebral ischemia and spinal cord injury via mechanisms that may include replacement of damaged cells, neuroprotective effects, induction of axonal sprouting, and neovascularization. Therapeutic effects have been reported in animal models of stroke after intravenous delivery of MSCs, including those derived from adult human bone marrow. Initial clinical studies on intravenously delivered MSCs have now been completed in human subjects with stroke. Here, we review the reparative and protective properties of transplanted MSCs in stroke models, describe initial human studies on intravenous MSC delivery in stroke, and provide a perspective on prospects for future progress with MSCs. |
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| AbstractList | Adult bone marrow-derived mesenchymal stem cells (MSCs) display a spectrum of functional properties. Transplantation of these cells improves clinical outcome in models of cerebral ischemia and spinal cord injury via mechanisms that may include replacement of damaged cells, neuroprotective effects, induction of axonal sprouting, and neovascularization. Therapeutic effects have been reported in animal models of stroke after intravenous delivery of MSCs, including those derived from adult human bone marrow. Initial clinical studies on intravenously delivered MSCs have now been completed in human subjects with stroke. Here, we review the reparative and protective properties of transplanted MSCs in stroke models, describe initial human studies on intravenous MSC delivery in stroke, and provide a perspective on prospects for future progress with MSCs. Adult bone marrow-derived mesenchymal stem cells (MSCs) display a spectrum of functional properties. Transplantation of these cells improves clinical outcome in models of cerebral ischemia and spinal cord injury via mechanisms that may include replacement of damaged cells, neuroprotective effects, induction of axonal sprouting, and neovascularization. Therapeutic effects have been reported in animal models of stroke after intravenous delivery of MSCs, including those derived from adult human bone marrow. Initial clinical studies on intravenously delivered MSCs have now been completed in human subjects with stroke. Here, we review the reparative and protective properties of transplanted MSCs in stroke models, describe initial human studies on intravenous MSC delivery in stroke, and provide a perspective on prospects for future progress with MSCs.Adult bone marrow-derived mesenchymal stem cells (MSCs) display a spectrum of functional properties. Transplantation of these cells improves clinical outcome in models of cerebral ischemia and spinal cord injury via mechanisms that may include replacement of damaged cells, neuroprotective effects, induction of axonal sprouting, and neovascularization. Therapeutic effects have been reported in animal models of stroke after intravenous delivery of MSCs, including those derived from adult human bone marrow. Initial clinical studies on intravenously delivered MSCs have now been completed in human subjects with stroke. Here, we review the reparative and protective properties of transplanted MSCs in stroke models, describe initial human studies on intravenous MSC delivery in stroke, and provide a perspective on prospects for future progress with MSCs. |
| Author | Honmou, Osamu Onodera, Rie Waxman, Stephen G. Sasaki, Masanori Kocsis, Jeffery D. |
| Author_xml | – sequence: 1 givenname: Osamu surname: Honmou fullname: Honmou, Osamu email: honmou@sapmed.ac.jp organization: Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University, South-1st, West-16th, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan – sequence: 2 givenname: Rie surname: Onodera fullname: Onodera, Rie organization: Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University, South-1st, West-16th, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan – sequence: 3 givenname: Masanori surname: Sasaki fullname: Sasaki, Masanori organization: Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University, South-1st, West-16th, Chuo-ku, Sapporo, Hokkaido 060-8543, Japan – sequence: 4 givenname: Stephen G. surname: Waxman fullname: Waxman, Stephen G. organization: Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA – sequence: 5 givenname: Jeffery D. surname: Kocsis fullname: Kocsis, Jeffery D. organization: Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22459358$$D View this record in MEDLINE/PubMed |
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| Snippet | Adult bone marrow-derived mesenchymal stem cells (MSCs) display a spectrum of functional properties. Transplantation of these cells improves clinical outcome... |
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| SubjectTerms | Animals Cell- and Tissue-Based Therapy Disease Models, Animal Humans Mesenchymal Stem Cell Transplantation Pathology Stroke - therapy |
| Title | Mesenchymal stem cells: therapeutic outlook for stroke |
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