Hsp90 up-regulates PD-L1 to promote HPV-positive cervical cancer via HER2/PI3K/AKT pathway

• Published in: Molecular medicine (Cambridge, Mass.) Vol. 27; no. 1; pp. 130 - 12
• Main Authors: Zeng, Jie, He, Si-Li, Li, Li-Jie, Wang, Chen
• Format: Journal Article
• Language: English
• Published: England BioMed Central 19.10.2021; BMC
• Subjects: Animals; B7-H1 Antigen - genetics; B7-H1 Antigen - metabolism; Cell Line, Tumor; Cervical cancer; Female; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques - methods; HER2; HPV16; Hsp90; HSP90 Heat-Shock Proteins - genetics; HSP90 Heat-Shock Proteins - metabolism; Human papillomavirus 16 - physiology; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Papillomavirus Infections - genetics; Papillomavirus Infections - metabolism; Papillomavirus Infections - virology; PD-L1; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Receptor, ErbB-2 - genetics; Receptor, ErbB-2 - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction - genetics; Transferases - genetics; Transferases - metabolism; Uterine Cervical Neoplasms - genetics; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - virology; Xenograft Model Antitumor Assays - methods; Hsp90; PD-L1; HER2; Cervical cancer; HPV16

HPV16 is the predominant cancer-causing strain that is responsible for over 50% of all cervical cancers. In this study, we aim to investigate the therapeutic effect of heat shock protein 90 (Hsp90) knockdown on HPV16 cervical cancer progression and the underlying mechanism. The transcript and protei...