Comparison of chromosomal status in reserved multiple displacement amplification products of embryos that resulted in miscarriages or live births: a blinded, nonselection case–control study

• Published in: BMC medical genomics Vol. 15; no. 1; pp. 35 - 8
• Main Authors: Yang, Guoxia, Xu, Yan, Zeng, Yanhong, Guo, Jing, Pan, Jiafu, Zhou, Canquan, Xu, Yanwen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 23.02.2022; BioMed Central; BMC
• Subjects: Abortion, Spontaneous - genetics; Abortion, Spontaneous - pathology; Aneuploidy; Blastocyst - pathology; Case studies; Case-Control Studies; Chromosomal abnormalities; Chromosomes; Embryonic development; Female; Genetic aspects; Genetic Testing - methods; Health aspects; Humans; Live Birth; Miscarriage; Mosaicism; Patient outcomes; Pregnancy; Preimplantation Diagnosis - methods; Preimplantation genetic testing for aneuploidy screening (PGT-A); Preimplantation genetic testing for monogenic disorders (PGT-Ms); China; Chromosomal abnormalities; Mosaicism; Preimplantation genetic testing for monogenic disorders (PGT-Ms); Preimplantation genetic testing for aneuploidy screening (PGT-A)

To analyze chromosomal status in reserved multiple displacement amplification (MDA) products of embryos that result in miscarriages or live births. Patients who underwent preimplantation genetic testing for monogenic disorders (PGT-Ms) without aneuploidy screening were included. The case group inclu...