Stromal response to Hedgehog signaling restrains pancreatic cancer progression

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 111; no. 30; pp. E3091 - E3100
• Main Authors: Lee, John J., Perera, Rushika M., Wang, Huaijun, Wu, Dai-Chen, Liu, X. Shawn, Han, Shiwei, Fitamant, Julien, Jones, Phillip D., Ghanta, Krishna S., Kawano, Sally, Nagle, Julia M., Deshpande, Vikram, Boucher, Yves, Kato, Tomoyo, Chen, James K., Willmann, Jürgen K., Bardeesy, Nabeel, Beachy, Philip A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 29.07.2014; National Acad Sciences
• Series: PNAS Plus
• Subjects: adenocarcinoma; agonists; animal models; Animals; Biological Sciences; carcinogenesis; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; clinical trials; epithelium; fibroblasts; Genetic engineering; Hedgehog Proteins - antagonists & inhibitors; Hedgehog Proteins - genetics; Hedgehog Proteins - metabolism; Humans; hyperplasia; ligands; Mice; Mice, Knockout; Molecules; Pancreatic cancer; pancreatic neoplasms; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Pharmacology; PNAS Plus; Proto-Oncogene Proteins p21(ras) - genetics; Proto-Oncogene Proteins p21(ras) - metabolism; Rodents; Signal Transduction; Sonic hedgehog; cancer therapy; hedgehog agonist; tumor stroma; cerulein

Pancreatic ductal adenocarcinoma (PDA) is the most lethal of common human malignancies, with no truly effective therapies for advanced disease. Preclinical studies have suggested a therapeutic benefit of targeting the Hedgehog (Hh) signaling pathway, which is activated throughout the course of PDA p...