Stromal response to Hedgehog signaling restrains pancreatic cancer progression - Lee, John J.; Perera, Rushika M.; Wang, Huaijun; Wu, Dai-Chen; Liu, X. Shawn; Han, Shiwei; Fitamant, Julien; Jones, Phillip D.; Ghanta, Krishna S.; Kawano, Sally; Nagle, Julia M.; Deshpande, Vikram; et al. (Proceedings of the National Academy of Sciences - PNAS, 2014)
Keywords: adenocarcinoma; agonists; animal models; Animals; Biological Sciences; carcinogenesis; Carcinoma, Pancreatic Ductal - drug therapy; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; clinical trials; epithelium; fibroblasts; Genetic engineering; Hedgehog Proteins - antagonists & inhibitors; Hedgehog Proteins - genetics; Hedgehog Proteins - metabolism; Humans; hyperplasia; ligands; Mice; Mice, Knockout; Molecules; Pancreatic cancer; pancreatic neoplasms; Pancreatic Neoplasms - drug therapy; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Pharmacology; PNAS Plus; Proto-Oncogene Proteins p21(ras) - genetics; Proto-Oncogene Proteins p21(ras) - metabolism; Rodents; Signal Transduction; Sonic hedgehog; cancer therapy; hedgehog agonist; tumor stroma; cerulein