Clinical trial: pilot study of metformin for the treatment of non‐alcoholic steatohepatitis

• Published in: Alimentary pharmacology & therapeutics Vol. 29; no. 2; pp. 172 - 182
• Main Authors: LOOMBA, R., LUTCHMAN, G., KLEINER, D. E., RICKS, M., FELD, J. J., BORG, B. B., MODI, A., NAGABHYRU, P., SUMNER, A. E., LIANG, T. J., HOOFNAGLE, J. H.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2009; Blackwell
• Subjects: Adult; Biological and medical sciences; Biopsy; Digestive system; Fatty Liver - drug therapy; Female; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Hypoglycemic Agents - therapeutic use; Liver - drug effects; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Metformin - therapeutic use; Middle Aged; Other diseases. Semiology; Pharmacology. Drug treatments; Pilot Projects; Statistics as Topic; Treatment Outcome; Human; Hypoglycemic agent; Biguanides; Treatment; Non alcoholic steatohepatitis; Digestive diseases; Hepatic disease; Clinical trial; Metformin

Summary Background  Non‐alcoholic steatohepatitis (NASH) is a form of progressive fatty liver disease that is strongly associated with insulin resistance, which suggests that insulin sensitizing agents such as metformin may be beneficial for NASH. Aim  To assess the effects of metformin on insulin s...