Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4+ T cells

• Published in: PloS one Vol. 16; no. 10; p. e0258316
• Main Authors: Wilson, Paul A., Santos Franco, Sara, He, Liu, Galwey, Nicholas W., Meakin, Jackie, McIntyre, Rebecca, McHugh, Simon M., Nolan, Michael A., Spain, Sarah L., Carlson, Thaddeus, Lobera, Mercedes, Rubio, Justin P., Davis, Bill, McCarthy, Linda C.
• Format: Journal Article
• Language: English
• Published: San Francisco Public Library of Science 21.10.2021; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Allergic reaction; Allergies; Allergy; Animal models; Autoimmune diseases; CD4 antigen; CD4 lymphocytes; Cell culture; Cell differentiation; Cellular communication; Culture; Detoxification; Development and progression; Differentiation (biology); Disease; Driving conditions; Gene expression; Genetic aspects; Genetic transcription; Genetic variation; Genome-wide association studies; Genomes; Genotypes; Health aspects; Helper cells; Hormone receptors; Hypersensitivity; Inflammatory bowel disease; Inflammatory bowel diseases; Inverse agonists; Lymphocytes; Lymphocytes T; Medical research; Medicine, Experimental; Metabolic pathways; Metabolism; Metabolites; Mutation; Perturbation; R&D; Receptors; Research & development; Signal transduction; Therapeutic targets; Transcription; United Kingdom; England; Victoria Australia; United Kingdom > UK; Australia; United States > US

RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As murine Th17-driven inflammatory disease models were greatly diminished in RORC knock-out mice, this receptor was prioritised as an attractive therapeutic target for the...