The role of oxidative stress in Rett syndrome: an overview

• Published in: Annals of the New York Academy of Sciences Vol. 1259; no. 1; pp. 121 - 135
• Main Authors: De Felice, Claudio, Signorini, Cinzia, Leoncini, Silvia, Pecorelli, Alessandra, Durand, Thierry, Valacchi, Giuseppe, Ciccoli, Lucia, Hayek, Joussef
• Format: Journal Article
• Language: English
• Published: Malden, USA Blackwell Publishing Inc 01.07.2012; Wiley Subscription Services, Inc; Wiley
• Subjects: Animal models; Animals; Chemical Sciences; Female; Genetic Association Studies; Heterogeneity; Humans; isoprostanes; MeCP2; Molecular Targeted Therapy - trends; Mutation; Organic chemistry; Oxidative stress; Oxidative Stress - genetics; Oxidative Stress - physiology; Quality of life; Rett syndrome; Rett Syndrome - etiology; Rett Syndrome - genetics; Rett Syndrome - metabolism; Rett Syndrome - therapy; MeCP2; isoprostanes; oxidative stress; Rett syndrome

The main cause of Rett syndrome (RTT), a pervasive development disorder almost exclusively affecting females, is a mutation in the methyl‐CpG binding protein 2 (MeCP2) gene. To date, no cure for RTT exists, although disease reversibility has been demonstrated in animal models. Emerging evidence from...