Behavioral characteristics and c-Fos expression in the medullary dorsal horn in a rat model for orofacial cancer pain

• Published in: European journal of pain Vol. 13; no. 4; p. 373
• Main Authors: Ono, Kentaro, Harano, Nozomu, Nagahata, Sawako, Seta, Yuji, Tsujisawa, Toshiyuki, Inenaga, Kiyotoshi, Nakanishi, Osamu
• Format: Journal Article
• Language: English
• Published: England 01.04.2009
• Subjects: Animals; Biomarkers - analysis; Biomarkers - metabolism; Cell Line, Tumor; Disease Models, Animal; Facial Pain - metabolism; Facial Pain - physiopathology; Feeding Behavior - physiology; Grooming - physiology; Head and Neck Neoplasms - complications; Hyperalgesia - metabolism; Hyperalgesia - physiopathology; Male; Neoplasms, Experimental - complications; Nociceptors - physiology; Physical Stimulation; Proto-Oncogene Proteins c-fos - metabolism; Rats; Rats, Wistar; Sensory Receptor Cells - cytology; Sensory Receptor Cells - metabolism; Trigeminal Caudal Nucleus - cytology; Trigeminal Caudal Nucleus - metabolism; Trigeminal Nerve - physiology; Vibrissae - physiology

It is well known that patients with orofacial cancer suffer from cancer-induced pain which produces feeding difficulties. To understand the mechanisms of pain associated with orofacial cancer, we have recently created a model for rat orofacial cancer by inoculation with Walker carcinosarcoma 256B-ce...