Inter-generational link of obesity in term and preterm births: role of maternal plasma acylcarnitines

• Published in: International Journal of Obesity Vol. 43; no. 10; pp. 1967 - 1977
• Main Authors: Wang, Guoying, Sun, Qi, Liang, Liming, Clash, Clary, Zhang, Cuilin, Hong, Xiumei, Ji, Yuelong, Radovick, Sally, Pearson, Colleen, Bartell, Tami R., Zuckerman, Barry, Cheng, Tina L., Hu, Frank B., Wang, Xiaobin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.10.2019; Nature Publishing Group
• Subjects: 692/308; 692/308/174; 692/499; Adolescent; Adult; Age; Biomarkers - blood; Body Mass Index; Body weight; Boston - epidemiology; Carnitine; Carnitine - analogs & derivatives; Carnitine - blood; Child; Child, Preschool; Children; Epidemiology; Fatty acids; Female; Health aspects; Health care facilities; Health Promotion and Disease Prevention; Humans; Infant; Infant, Newborn; Infants (Premature); Insulin; Intergenerational transmission; Intermediates; Internal Medicine; Liquid chromatography; Male; Mass spectrometry; Mass spectroscopy; Medicine; Medicine & Public Health; Metabolic Diseases; Mothers; Mothers - education; Mothers - statistics & numerical data; Obesity; Obesity - blood; Obesity - complications; Obesity - epidemiology; Obesity - physiopathology; Obesity in children; Offspring; Overweight; Oxidation; Oxidation resistance; Pediatric Obesity - blood; Pediatric Obesity - epidemiology; Pediatric Obesity - etiology; Physiological aspects; Pregnancy; Premature birth; Premature Birth - blood; Prenatal Exposure Delayed Effects - blood; Prenatal influences; Prospective Studies; Public Health; Risk analysis; Risk factors; Boston; United States

Background/objectives Acylcarnitines, intermediates of fatty acid oxidation, are known to be involved in obesity and insulin resistance. Since maternal prepregnancy overweight or obesity (OWO) is a recognized major risk factor for offspring OWO, we hypothesized that maternal plasma acylcarnitines ma...