Systems biology of vaccination for seasonal influenza in humans

• Published in: Nature immunology Vol. 12; no. 8; pp. 786 - 795
• Main Authors: Nakaya, Helder I, Wrammert, Jens, Lee, Eva K, Racioppi, Luigi, Marie-Kunze, Stephanie, Haining, W Nicholas, Means, Anthony R, Kasturi, Sudhir P, Khan, Nooruddin, Li, Gui-Mei, McCausland, Megan, Kanchan, Vibhu, Kokko, Kenneth E, Li, Shuzhao, Elbein, Rivka, Mehta, Aneesh K, Aderem, Alan, Subbarao, Kanta, Ahmed, Rafi, Pulendran, Bali
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.08.2011; Nature Publishing Group
• Subjects: 631/250/251/1567; 631/250/255/1578; 631/553; Adaptive Immunity - immunology; Adolescent; Adult; Animals; Antibodies; Antibodies, Viral - blood; Antigens; B cells; Biology; Biomedical and Life Sciences; Biomedicine; Biotechnology industries; Ca2+/calmodulin-dependent protein kinase IV; Care and treatment; Clinical trials; Gene expression; Gene Expression Profiling; Genetic aspects; Hemagglutination Inhibition Tests; Humans; Immunity, Innate - immunology; Immunization; Immunogenicity; Immunology; Infectious Diseases; Influenza; Influenza vaccines; Influenza Vaccines - administration & dosage; Influenza Vaccines - immunology; Influenza, Human - immunology; Influenza, Human - prevention & control; Medical schools; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Orthomyxoviridae - immunology; resource; Seasons; Systems Biology - methods; Vaccination; Vaccination - methods; Vaccines; Vaccines, Attenuated - administration & dosage; Vaccines, Attenuated - immunology; Vaccines, Inactivated - administration & dosage; Vaccines, Inactivated - immunology; Young Adult; United States

Identifying molecular predictors of effective vaccination is an important clinical and technical goal. Pulendran and colleagues use a systems biology approach to study human responses to vaccination against influenza and determine the correlates of immunogenicity. Here we have used a systems biology...