The preponderance of nonsynonymous A-to-I RNA editing in coleoids is nonadaptive

• Published in: Nature communications Vol. 10; no. 1; pp. 5411 - 10
• Main Authors: Jiang, Daohan, Zhang, Jianzhi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 27.11.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 45/91; 631/181/735; 631/208/212/2019; Adaptation, Biological - genetics; Adenosine; Adenosine - genetics; Animals; Cephalopoda; Cephalopoda - genetics; Editing; Guanine; Humanities and Social Sciences; Inosine - genetics; multidisciplinary; Octopuses; RNA Editing; Science; Transcriptome

A-to-I editing enzymatically converts the base adenosine (A) in RNA molecules to inosine (I), which is recognized as guanine (G) in translation. Exceptionally abundant A-to-I editing was recently discovered in the neural tissues of coleoids (octopuses, squids, and cuttlefishes), with a greater fract...