Cerebellar Kv3.3 potassium channels activate TANK-binding kinase 1 to regulate trafficking of the cell survival protein Hax-1

• Published in: Nature communications Vol. 12; no. 1; pp. 1731 - 17
• Main Authors: Zhang, Yalan, Varela, Luis, Szigeti-Buck, Klara, Williams, Adam, Stoiljkovic, Milan, Šestan-Peša, Matija, Henao-Mejia, Jorge, D’Acunzo, Pasquale, Levy, Efrat, Flavell, Richard A., Horvath, Tamas L., Kaczmarek, Leonard K.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/109; 13/2; 13/95; 14; 14/28; 45/23; 45/70; 49/47; 631/378; 64/110; 692/617; 82/80; 9/26; 9/74; Animals; Apoptosis; Ataxia; Binding; Cell death; Cell survival; Cell Survival - physiology; Cerebellar ataxia; Cerebellum; Cerebellum - metabolism; Degeneration; Depolarization; Enzymes; Exosomes - metabolism; Female; Humanities and Social Sciences; Inactivation; Interneurons - metabolism; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Ion channels; Kinases; Lysosomes; Male; Membrane proteins; Membrane trafficking; Mice; multidisciplinary; Mutation; Neurons; Phenotype; Potassium; Potassium channels (voltage-gated); Protein Serine-Threonine Kinases - genetics; Protein Serine-Threonine Kinases - metabolism; Protein transport; Protein Transport - physiology; Proteins; Science; Science (multidisciplinary); Shaw Potassium Channels - genetics; Shaw Potassium Channels - metabolism; Signal Transduction; Survival

Mutations in KCNC3 , which encodes the Kv3.3 potassium channel, cause degeneration of the cerebellum, but exactly how the activity of an ion channel is linked to the survival of cerebellar neurons is not understood. Here, we report that Kv3.3 channels bind and stimulate Tank Binding Kinase 1 (TBK1),...