Association of sequence variations in the gene encoding insulin-like growth factor binding protein 5 with adiponectin

• Published in: International Journal of Obesity Vol. 33; no. 1; pp. 80 - 88
• Main Authors: Kallio, P, Tolppanen, A.M, Kolehmainen, M, Poutanen, K, Lindström, J, Tuomilehto, J, Kuulasmaa, T, Kuusisto, J, Pulkkinen, L, Uusitupa, M
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.01.2009; Nature Publishing Group
• Subjects: adiponectin; Adiponectin - metabolism; Adipose tissue; Binding proteins; biochemical pathways; Biological and medical sciences; Body Mass Index; Chi-Square Distribution; Cross-Sectional Studies; Deoxyribonucleic acid; Diabetes; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - metabolism; Discrimination; disease incidence; DNA; Epidemiology; Female; Finland; Finland - epidemiology; Finnish Diabetes Prevention Study; Gender; gender differences; Gene Frequency; genes; Genetic aspects; Genetic diversity; genetic variation; Health Promotion and Disease Prevention; Humans; Incidence; Insulin Resistance - genetics; insulin-like growth factor binding protein 5; Insulin-Like Growth Factor Binding Protein 5 - genetics; insulin-like growth factor binding proteins; Insulin-like growth factors; Internal Medicine; Linkage Disequilibrium; Longitudinal studies; Male; Medical sciences; Medicine; Medicine & Public Health; men; Metabolic Diseases; Metabolic disorders; metabolic syndrome; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Metabolic syndrome X; Middle Aged; Miscellaneous; noninsulin-dependent diabetes mellitus; nucleotide sequences; nutrition physiology; Obesity; original-article; Other metabolic disorders; Polymorphism, Single Nucleotide; Prevention; Properties; Public Health; single nucleotide polymorphism; Subcutaneous Fat - metabolism; women; Finland; metabolic syndrome; adiponectin; association; genotyping; Endocrinopathy; Obesity; Nutrition; IGFBP5; Nutrition disorder; Cardiovascular disease; Genotype; Metabolic diseases; Metabolic syndrome; Adiponectin; Association; Insulin-like growth factor binding protein-5; Gene; Genetics; Nutritional status; Polymorphism
• ISSN: 0307-0565; 1476-5497; 1476-5497
• DOI: 10.1038/ijo.2008.196

Background: Insulin-like growth factor binding protein 5 (IGFBP5) binds to IGF and thus modulates IGF signaling pathway. We have shown earlier that the IGFBP5 gene was downregulated in the adipose tissue after 12-week carbohydrate diet with low insulinemic response. Objective: The aim was to examine...