Ferroptosis is an autophagic cell death process

• Published in: Cell research Vol. 26; no. 9; pp. 1021 - 1032
• Main Authors: Gao, Minghui, Monian, Prashant, Pan, Qiuhui, Zhang, Wei, Xiang, Jenny, Jiang, Xuejun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2016; Nature Publishing Group
• Subjects: 631/45/49; 631/80/82/39; Animals; Apoptosis - drug effects; Autophagy - drug effects; Biomedical and Life Sciences; Cell Biology; Cell death; Ferritins - metabolism; Ferroptosis; Genetic Testing; Homeostasis - drug effects; Humans; Iron; Iron - pharmacology; Life Sciences; Mice; Mortality; Nuclear Receptor Coactivators - metabolism; Original; original-article; Reactive Oxygen Species - metabolism; RNA Interference; ferritinophagy; ferroptosis; autophagy; iron homeostasis; reactive oxygen species
• ISSN: 1001-0602; 1748-7838
• DOI: 10.1038/cr.2016.95

Ferroptosis is an iron-dependent form of regulated necrosis. It is implicated in various human diseases, including ischemic organ damage and cancer. Here, we report the crucial role of autophagy, particularly autophagic degradation of cellular iron storage proteins （a process known as ferritinophagy...