Dynamics of epithelial–mesenchymal plasticity driving cancer drug resistance

• Published in: Cancer pathogenesis and therapy Vol. 3; no. 2; pp. 120 - 128
• Main Authors: Bangarh, Rashmi, Saini, Reena V., Saini, Adesh K., Singh, Tejveer, Joshi, Hemant, Ramniwas, Seema, Shahwan, Moyad, Tuli, Hardeep Singh
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2025; Elsevier
• Subjects: Cancer drug resistance; Epithelial–mesenchymal transition; Metastasis; Review; Tumor microenvironment; Epithelial–mesenchymal transition; Metastasis; Tumor microenvironment; Cancer drug resistance

Epithelial–mesenchymal transition (EMT) promotes several cancers by increasing tumor cell motility, disrupting epithelial cell phenotypes, apical–basal polarity, and intracellular connections, and enhancing tumor resistance to immunotherapy and chemotherapy. Mesenchymal–epithelial transition (MET),...