Bioprinted Multi-Cell Type Lung Model for the Study of Viral Inhibitors

• Published in: Viruses Vol. 13; no. 8; p. 1590
• Main Authors: Berg, Johanna, Weber, Zia, Fechler-Bitteti, Mona, Hocke, Andreas C., Hippenstiel, Stefan, Elomaa, Laura, Weinhart, Marie, Kurreck, Jens
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 11.08.2021; MDPI
• Subjects: A549 Cells; alginates; Alginic acid; Alveoli; Animal models; antiviral agents; Antiviral Agents - pharmacology; Antiviral drugs; Bioprinting; Cell culture; Collagen; dose response; Drug development; epithelium; Fibroblasts; Gelatin; Glucose; Host-Pathogen Interactions - drug effects; human lung model; Humans; Hydrogels; IL-1β; Immune response; In Vitro Techniques - methods; Infections; Inflammation; Influenza; Influenza A; Influenza A virus; Influenza A virus - drug effects; Influenza A virus - pathogenicity; Interleukin 8; Lipopolysaccharides; LPS stimulation; Lung - cytology; Lung - drug effects; Lung - virology; Lungs; Monocytes; Physiology; Shear strain; therapeutics; THP-1 Cells; viability; Viral infections; Virus Replication - drug effects; Viruses; Viscoelasticity; Viscosity; United Kingdom > UK; United States > US; Germany; human lung model; LPS stimulation; bioprinting; influenza A virus

Influenza A virus (IAV) continuously causes epidemics and claims numerous lives every year. The available treatment options are insufficient and the limited pertinence of animal models for human IAV infections is hampering the development of new therapeutics. Bioprinted tissue models support studyin...