Study of New Therapeutic Strategies to Combat Breast Cancer Using Drug Combinations

• Published in: Biomolecules (Basel, Switzerland) Vol. 8; no. 4; p. 175
• Main Authors: Correia, Ana, Silva, Dany, Correia, Alexandra, Vilanova, Manuel, Gärtner, Fátima, Vale, Nuno
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 14.12.2018; MDPI
• Subjects: 5-Fluorouracil; Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols - pharmacology; Breast cancer; Breast Neoplasms - drug therapy; Breast Neoplasms - pathology; Cancer therapies; Cell cycle; Cell death; Cell proliferation; Cell viability; Clinical trials; Cytotoxicity; Disease; drug combinations; drug repurposing; Drug resistance; Drug Resistance, Neoplasm - drug effects; Drug therapy; epithelial-mesenchymal transition; Epithelial-Mesenchymal Transition - drug effects; Female; Fluorouracil - pharmacology; Humans; Itraconazole; Itraconazole - pharmacology; MCF-7 Cells; Mesenchyme; Metastasis; R&D; Radiation therapy; Research & development; Research & development expenditures; Verapamil; Verapamil - pharmacology; 5-fluorouracil; breast cancer; epithelial-mesenchymal transition; cell viability; drug repurposing; drug combinations

Cancer is a disease that affects and kills millions of people worldwide. Breast cancer, especially, has a high incidence and mortality, and is challenging to treat. Due to its high impact on the health sector, oncological therapy is the subject of an intense and very expensive research. To improve t...