The Down-Regulation of MicroRNA-497 Contributes to Cell Growth and Cisplatin Resistance Through PI3K/Akt Pathway in Osteosarcoma

• Published in: Cellular physiology and biochemistry Vol. 36; no. 5; pp. 2051 - 2062
• Main Authors: Shao, Xue-jun, Miao, Mei-hua, Xue, Jun, Xue, Jian, Ji, Xue-qiang, Zhu, Hong
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland Cell Physiol Biochem Press GmbH & Co KG 01.01.2015
• Subjects: Antineoplastic Agents - toxicity; Bone Neoplasms - enzymology; Bone Neoplasms - pathology; Cell Division - drug effects; Cell Division - genetics; Cell Line, Tumor; Cisplatin; Cisplatin - toxicity; Down-Regulation; Humans; microRNA-497; MicroRNAs - genetics; Original Paper; Osteosarcoma; Osteosarcoma - enzymology; Osteosarcoma - pathology; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; VEGFA; microRNA-497; Osteosarcoma; Cisplatin; VEGFA

Background: Down-expression of microRNA-497 (miR-497) was often found in malignancies. The purposes of this study were to determine the expression of miR-497 in human osteosarcoma and to establish the association between miR-497 expression with cell survival and the sensitivity to cisplatin in human...