Antigenic Change in Human Influenza A(H2N2) Viruses Detected by Using Human Plasma from Aged and Younger Adult Individuals

• Published in: Viruses Vol. 11; no. 11; p. 978
• Main Authors: Matsuzawa, Yukimasa, Iwatsuki-Horimoto, Kiyoko, Nishimoto, Yoshinori, Abe, Yukiko, Fukuyama, Satoshi, Hamabata, Taiki, Okuda, Moe, Go, Yui, Watanabe, Tokiko, Imai, Masaki, Arai, Yasumichi, Fouchier, Ron A.M., Yamayoshi, Seiya, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.10.2019; MDPI
• Subjects: adults; aged individuals; Amino acids; antigenic change; antigenic drift; Antigenicity; Antisera; antiserum; Binding sites; Cartography; Eggs; Experiments; ferrets; h2n2; human influenza; humans; Immune imprinting; Influenza; Influenza A; Influenza A virus; Maximum likelihood method; mice; Monoclonal antibodies; Mutation; neutralization; neutralizing antibodies; Pandemics; Phylogenetics; Plasma; Surveillance; Trees; Vaccines; Viruses; Netherlands; Japan; aged individuals; antigenic change; antigenic drift; H2N2; influenza A virus

Human influenza A(H2N2) viruses emerged in 1957 and were replaced by A(H3N2) viruses in 1968. The antigenicity of human H2N2 viruses has been tested by using ferret antisera or mouse and human monoclonal antibodies. Here, we examined the antigenicity of human H2N2 viruses by using human plasma sampl...