Sleep-disordered breathing, circulating exosomes, and insulin sensitivity in adipocytes

• Published in: International Journal of Obesity Vol. 42; no. 6; pp. 1127 - 1139
• Main Authors: Khalyfa, Abdelnaby, Gozal, David, Masa, Juan F, Marin, José Maria, Qiao, Zhuanghong, Corral, Jaime, González, Mónica, Marti, Sergi, Kheirandish-Gozal, Leila, Egea, Carlos, Sánchez-Quiroga, M-Ángeles, de Terreros, Francisco J Gómez, Barca, F Javier
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2018; Nature Publishing Group
• Subjects: 13/106; 14/19; 631/1647/767/1424; 64/60; 692/699/2743/393; 82/1; 96/95; Adipocytes; Adults; AKT protein; Animal models; Breathing; Cell culture; Complications and side effects; Continuous positive airway pressure; Development and progression; Differentiation; Epidemiology; Exosomes; Fasting; Fragmentation; Glycerol; Health aspects; Health Promotion and Disease Prevention; House mouse; Hypoventilation; Hypoxia; Insulin; Insulin resistance; Internal Medicine; Lipolysis; Medical schools; Medicine; Medicine & Public Health; Metabolic Diseases; Metabolism; Mice; MicroRNA; Mimicry; miRNA; Obesity; Organelles; Patients; Phosphorylation; Physiological aspects; Physiological effects; Plasma; Public Health; Respiration; Risk factors; Sensitivity analysis; Sleep; Sleep apnea; Sleep disorders; Western blotting

Background: Sleep-disordered-breathing (SDB), which is characterized by chronic intermittent hypoxia (IH) and sleep fragmentation (SF), is a prevalent condition that promotes metabolic dysfunction, particularly among patients suffering from obstructive hypoventilation syndrome (OHS). Exosomes are ge...