Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome

• Published in: Scientific reports Vol. 11; no. 1; pp. 5585 - 14
• Main Authors: Moore, Robert, Puniya, Bhanwar Lal, Powers, Robert, Guda, Chittibabu, Bayles, Kenneth W., Berkowitz, David B., Helikar, Tomáš
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/114/2404; 631/154/555; 631/337/2019; Drug development; Gamma rays; Gelatinase B; Gene expression; Humanities and Social Sciences; Long-term effects; multidisciplinary; Radiation; Science; Science (multidisciplinary); Therapeutic targets; ZAP-70 protein

Recent political unrest has highlighted the importance of understanding the short- and long-term effects of gamma-radiation exposure on human health and survivability. In this regard, effective treatment for acute radiation syndrome (ARS) is a necessity in cases of nuclear disasters. Here, we propos...