Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

• Published in: Inflammation research Vol. 69; no. 9; pp. 883 - 895
• Main Authors: Chen, Xuxin, Tang, Jian, Shuai, Weizheng, Meng, Jiguang, Feng, Jian, Han, Zhihai
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.09.2020; Springer Nature B.V
• Subjects: Acute Lung Injury - etiology; Allergology; Biomedical and Life Sciences; Biomedicine; Cell Polarity; Dermatology; Humans; Immunology; Inflammation; JNK Mitogen-Activated Protein Kinases - physiology; Literature reviews; Lungs; Macrophages; Macrophages - physiology; Neurology; NF-kappa B - physiology; Pathogenesis; Pharmacology/Toxicology; Polarization; Regulation; Regulatory mechanisms (biology); Respiratory distress syndrome; Respiratory Distress Syndrome - etiology; Review; Rheumatology; Signal Transduction - physiology; Therapeutic applications; Therapeutic targets; Transforming Growth Factor beta - physiology; Acute respiratory distress syndrome; Acute lung injury; Macrophage polarization; Macrophage

Purpose Macrophages are highly plastic cells. Under different stimuli, macrophages can be polarized into several different subsets. Two main macrophage subsets have been suggested: classically activated or inflammatory (M1) macrophages and alternatively activated or anti-inflammatory (M2) macrophage...