Cross-Reactive Antibodies to SARS-CoV-2 and MERS-CoV in Pre-COVID-19 Blood Samples from Sierra Leoneans

• Published in: Viruses Vol. 13; no. 11; p. 2325
• Main Authors: Borrega, Rodrigo, Nelson, Diana K. S., Koval, Anatoliy P., Bond, Nell G., Heinrich, Megan L., Rowland, Megan M., Lathigra, Raju, Bush, Duane J., Aimukanova, Irina, Phinney, Whitney N., Koval, Sophia A., Hoffmann, Andrew R., Smither, Allison R., Bell-Kareem, Antoinette R., Melnik, Lilia I., Genemaras, Kaylynn J., Chao, Karissa, Snarski, Patricia, Melton, Alexandra B., Harrell, Jaikin E., Smira, Ashley A., Elliott, Debra H., Rouelle, Julie A., Sabino-Santos, Gilberto, Drouin, Arnaud C., Momoh, Mambu, Sandi, John Demby, Goba, Augustine, Samuels, Robert J., Kanneh, Lansana, Gbakie, Michael, Branco, Zoe L., Shaffer, Jeffrey G., Schieffelin, John S., Robinson, James E., Fusco, Dahlene N., Sabeti, Pardis C., Andersen, Kristian G., Grant, Donald S., Boisen, Matthew L., Branco, Luis M., Garry, Robert F.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.11.2021; MDPI
• Subjects: Age Distribution; Alphacoronavirus - immunology; Antibodies; Antibodies, Neutralizing - blood; Antibodies, Neutralizing - immunology; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antigens; Antigens, Viral - immunology; Betacoronavirus - immunology; blood; Blood & organ donations; Blood Donors; Coronaviridae; Coronavirus Nucleocapsid Proteins - immunology; Coronaviruses; COVID-19; COVID-19 - immunology; COVID-19 caseloads and deaths; COVID-19 infection; cross immunity; Cross Protection; Cross Reactions; E coli; Ebola virus; enzyme-linked immunosorbent assays; Epitopes; Female; Fever; Humans; Infections; Infectious diseases; Lassa fever; Lassa virus fever; Male; Medical research; Middle East respiratory syndrome; Middle East Respiratory Syndrome Coronavirus - immunology; pandemic; Pandemics; Phosphoproteins - immunology; pre-existing immunity to coronaviruses; Proteins; Pseudovirus; pseudovirus neutralizing antibodies; recombinant antigens; SARS-CoV-2 - immunology; Serology; Severe acute respiratory syndrome coronavirus 2; Sierra Leone; sub-Saharan Africa; United States; Viral Pseudotyping; United States; Sierra Leone; United States > US; Europe; Germany; Africa; severe acute respiratory syndrome coronavirus-2; sub-Saharan Africa; pseudovirus neutralizing antibodies; enzyme-linked immunosorbent assays; pre-existing immunity to coronaviruses; COVID-19 caseloads and deaths; recombinant antigens; Middle Eastern respiratory syndrome coronavirus

Many countries in sub-Saharan Africa have experienced lower COVID-19 caseloads and fewer deaths than countries in other regions worldwide. Under-reporting of cases and a younger population could partly account for these differences, but pre-existing immunity to coronaviruses is another potential fac...