Early impoverished environment delays the maturation of cerebral cortex

• Published in: Scientific reports Vol. 8; no. 1; pp. 1187 - 15
• Main Authors: Narducci, Roberta, Baroncelli, Laura, Sansevero, Gabriele, Begenisic, Tatjana, Prontera, Concetta, Sale, Alessandro, Cenni, Maria Cristina, Berardi, Nicoletta, Maffei, Lamberto
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 19.01.2018; Nature Publishing Group
• Subjects: 14/1; 14/34; 14/63; 59; 631/378/2571/1696; 631/378/3920; 64; 64/60; 9/30; Acuity; Animals; Axons - metabolism; Biomarkers; Body Weight; Central nervous system; Cerebral cortex; Cerebral Cortex - growth & development; Cerebral Cortex - metabolism; Cerebral Cortex - physiology; Evoked Potentials, Visual; Female; Fibers; Humanities and Social Sciences; Insulin; Insulin-like growth factor I; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factors; Juveniles; Latency; Living conditions; Male; Maternal-Fetal Relations; Maturation; Memory; Motor Activity; multidisciplinary; Myelin Sheath - metabolism; Myelination; Nervous system; Neurogenesis; Neurons - metabolism; Phosphorylation; Rats; Science; Sensorimotor integration; Somatosensory cortex; Visual Acuity; Visual Cortex; Visual evoked potentials; Visual pathways; Visual stimuli; Visual system; γ-Aminobutyric acid

The influence of exposure to impoverished environments on brain development is unexplored since most studies investigated how environmental impoverishment affects adult brain. To shed light on the impact of early impoverishment on developmental trajectories of the nervous system, we developed a prot...