Atorvastatin Affects Several Angiogenic Mediators in Human Endothelial Cells

• Published in: Endothelium (New York, N.Y.) Vol. 12; no. 5-6; pp. 233 - 241
• Main Authors: Dulak, Józef, Loboda, Agnieszka, Jazwa, Agnieszka, Zagorska, Anna, Dörler, Jacob, Alber, Hannes, Dichtl, Wolfgang, Weidinger, Franz, Frick, Matthias, Jozkowicz, Alicja
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 01.01.2005; Taylor & Francis
• Subjects: Atherosclerosis; Atorvastatin Calcium; Cancer; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells - cytology; Endothelial Cells - metabolism; Gene Expression Regulation - drug effects; Gene Expression Regulation - genetics; Heme Oxygenase-1; Heptanoic Acids - pharmacology; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - genetics; Interleukin 8; Neovascularization, Physiologic - drug effects; Neovascularization, Physiologic - genetics; Pyrroles - pharmacology; Vascular Endothelial Growth Factor

The pleiotropic effects of statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, have been recently extended to the modulation of angiogenesis. Here, to get more insight into the statins action, the authors have investigated the effect of atorvastatin on the expression of...