The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy - Wang, Gui-Zhen; Zhang, Li; Zhao, Xin-Chun; Gao, San-Hui; Qu, Li-Wei; Yu, Hong; Fang, Wen-Feng; Zhou, Yong-Chun; Liang, Fan; Zhang, Chen; Huang, Yun-Chao; Liu, Zhihua; et al. (Nature communications, 2019)
Keywords: 13/31; 13/51; 13/89; 13/95; 38/88; 42/89; 631/67/1612/1350; 692/4028/67/1612/1350; 82/1; 96/44; Adaptive immunity; Animal models; Animals; Antibodies; Antibodies, Monoclonal - pharmacology; Anticancer properties; Antitumor activity; Aromatic compounds; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - genetics; B7-H1 Antigen - immunology; Benzo(a)pyrene; Benzo(a)pyrene - toxicity; Benzoflavones - pharmacology; Cancer; Carcinogenesis; Carcinogens; Carcinogens - toxicity; Cell Line, Tumor; Cigarette smoke; Disease Models, Animal; Epithelial cells; Epithelium; Female; Gene Expression Regulation, Neoplastic; Humanities and Social Sciences; Humans; Hydrocarbons; Immunity; Immunotherapy; Immunotherapy - methods; Lung - drug effects; Lung - immunology; Lung - pathology; Lung cancer; Lung Neoplasms - etiology; Lung Neoplasms - genetics; Lung Neoplasms - mortality; Lung Neoplasms - therapy; Mice; Mice, Inbred C57BL; Monoclonal antibodies; multidisciplinary; Patients; PD-1 protein; PD-L1 protein; Pembrolizumab; Pyrene; Receptors; Receptors, Aryl Hydrocarbon - antagonists & inhibitors; Receptors, Aryl Hydrocarbon - genetics; Receptors, Aryl Hydrocarbon - immunology; Science; Signal Transduction; Small Cell Lung Carcinoma - etiology; Small Cell Lung Carcinoma - genetics; Small Cell Lung Carcinoma - mortality; Small Cell Lung Carcinoma - therapy; Smoke; Smoking; Smoking - adverse effects; Survival Analysis; Synergism; Targeted cancer therapy; Therapeutic applications; Therapeutic targets; Tobacco; Tobacco smoke; Tumorigenesis; Xenograft Model Antitumor Assays