Elevated IgE and atopy in patients treated for early-onset ADA-SCID

• Published in: Journal of allergy and clinical immunology Vol. 132; no. 6; pp. 1444 - 1446.e5
• Main Authors: Lawrence, Monica G., MD, Barber, John S., BA, Sokolic, Robert A., MD, Garabedian, Elizabeth K., RN, MSLS, Desai, Avanti N., MS, O'Brien, Michelle, RN, BSN, Jones, Nina, RN, BSN, Bali, Pawan, PhD, Hershfield, Michael S., MD, Stone, Kelly D., MD, PhD, Candotti, Fabio, MD, Milner, Joshua D., MD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.12.2013; Elsevier; Elsevier Limited
• Subjects: Adenosine Deaminase - genetics; Adolescent; Adult; Allergies; Allergy and Immunology; Biological and medical sciences; Bone marrow; Bone Marrow Transplantation; Cells, Cultured; Child; Child, Preschool; Cohort Studies; Cross-Sectional Studies; Cytokines - metabolism; Dermatitis; Drug therapy; Enzyme Replacement Therapy; Female; Food allergies; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Gene therapy; Genetic Therapy; Humans; Immune system; Immunoglobulin E - genetics; Immunoglobulin E - metabolism; Immunologic Memory; Infant; Male; Medical sciences; Mutation - genetics; Nose; Phenotype; Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis; Severe Combined Immunodeficiency - genetics; Severe Combined Immunodeficiency - immunology; Severe Combined Immunodeficiency - therapy; Th2 Cells - immunology; Young Adult; Human; Allergy; Immunopathology; IgE; Metabolic diseases; Adenosine deaminase deficiency; Enzymopathy; Genetic disease; Atopy; Immunology; Treatment; Age of onset; Early; Purine

Because nonatopic patients were much younger in our cohort, it is quite likely that many of them will go on to develop allergic disease as well.