Safety and immunogenicity of a candidate bioconjugate vaccine against Shigella dysenteriae type 1 administered to healthy adults: A single blind, partially randomized Phase I study - Hatz, Christoph F.R; Bally, Bettina; Rohrer, Susanne; Steffen, Robert; Kramme, Stefanie; Siegrist, Claire-Anne; Wacker, Michael; Alaimo, Cristina; Fonck, Veronica Gambillara (Vaccine, 2015)
Keywords: adjuvants; Adolescent; ADP Ribose Transferases - metabolism; Adult; adults; Age; Allergy and Immunology; Aluminum; antibodies; Antibodies, Bacterial - blood; Bacterial Toxins - metabolism; Bacterial Vaccines - administration & dosage; Bacterial Vaccines - adverse effects; Bacterial Vaccines - immunology; Bioconjugate; Body mass index; children; Developing countries; Drug Carriers - metabolism; Dysentery, Bacillary - prevention & control; endemic diseases; epitopes; exotoxins; Exotoxins - metabolism; Fatalities; Female; geometry; Haemophilus influenzae; Health care; Healthy Volunteers; Humans; humoral immunity; immune response; Immunogenicity; immunoglobulin G; Infections; LDCs; lipopolysaccharides; Male; manufacturing; markets; Middle Aged; morbidity; mortality; Neisseria meningitidis; O Antigens - immunology; pathogens; Proteins; Pseudomonas aeruginosa; Pseudomonas aeruginosa Exotoxin A; Reactogenicity; Saccharides; Safety; Shigella; Shigella dysenteriae; Shigella dysenteriae - immunology; Shigellosis; Single-Blind Method; Studies; sugars; vaccination; Vaccine; Vaccines; Vaccines, Conjugate - administration & dosage; Vaccines, Conjugate - adverse effects; Vaccines, Conjugate - immunology; Virulence Factors - metabolism; Young Adult; Southeast Asia; Vaccine; Bioconjugate; Safety; Immunogenicity; Shigella; Reactogenicity