Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia

• Published in: Nature communications Vol. 12; no. 1; pp. 2102 - 16
• Main Authors: Zhu, Xiangjia, Du, Yu, Li, Dan, Xu, Jie, Wu, Qingfeng, He, Wenwen, Zhang, Keke, Zhu, Jie, Guo, Linying, Qi, Ming, Liu, Ailin, Qi, Jiao, Wang, Guangyu, Meng, Jiaqi, Yang, Zhenglin, Zhang, Kang, Lu, Yi
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 14/34; 38/15; 38/39; 38/88; 59/57; 64/110; 64/60; 692/699/3161/3165; 692/699/3161/3168; 692/699/3161/3174; 692/699/3161/3175; 82/58; 82/80; Animal models; Animals; beta-Crystallins - biosynthesis; Blindness; Crystal structure; Crystallin; Crystallinity; Female; gamma-Crystallins - biosynthesis; Humanities and Social Sciences; Humans; Lens, Crystalline - growth & development; Lens, Crystalline - pathology; Lenses; Maf Transcription Factors - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; multidisciplinary; Myopia; Myopia, Degenerative - pathology; Promoter Regions, Genetic - genetics; Science; Science (multidisciplinary); Signaling; Smad protein; Smad Proteins - metabolism; Surgery; Therapeutic applications; Transcription factors; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-b1; Up-Regulation - genetics

High myopia is a leading cause of blindness worldwide. Myopia progression may lead to pathological changes of lens and affect the outcome of lens surgery, but the underlying mechanism remains unclear. Here, we find an increased lens size in highly myopic eyes associated with up-regulation of β/γ-cry...