Aberrant TGF-β1 signaling activation by MAF underlies pathological lens growth in high myopia - Zhu, Xiangjia; Du, Yu; Li, Dan; Xu, Jie; Wu, Qingfeng; He, Wenwen; Zhang, Keke; Zhu, Jie; Guo, Linying; Qi, Ming; Liu, Ailin; Qi, Jiao; et al. (Nature communications, 2021)
Keywords: 14/34; 38/15; 38/39; 38/88; 59/57; 64/110; 64/60; 692/699/3161/3165; 692/699/3161/3168; 692/699/3161/3174; 692/699/3161/3175; 82/58; 82/80; Animal models; Animals; beta-Crystallins - biosynthesis; Blindness; Crystal structure; Crystallin; Crystallinity; Female; gamma-Crystallins - biosynthesis; Humanities and Social Sciences; Humans; Lens, Crystalline - growth & development; Lens, Crystalline - pathology; Lenses; Maf Transcription Factors - metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; multidisciplinary; Myopia; Myopia, Degenerative - pathology; Promoter Regions, Genetic - genetics; Science; Science (multidisciplinary); Signaling; Smad protein; Smad Proteins - metabolism; Surgery; Therapeutic applications; Transcription factors; Transforming Growth Factor beta1 - metabolism; Transforming growth factor-b1; Up-Regulation - genetics