Screening of the Yeast yTHC Collection Identifies Essential Host Factors Affecting Tombusvirus RNA Recombination

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Published inJournal of Virology Vol. 80; no. 3; pp. 1231 - 1241
Main Authors Serviene, Elena, Jiang, Yi, Cheng, Chi-Ping, Baker, Jannine, Nagy, Peter D
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.02.2006
Subjects
Base Sequence
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genetic Diversity and Evolution
Genome, Fungal
Microbiology
Miscellaneous
Recombination, Genetic
Replicon
RNA, Fungal - genetics
RNA, Viral - genetics
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae - virology
Tomato bushy stunt virus
Tombusvirus
Tombusvirus - genetics
Tombusvirus - pathogenicity
Tombusvirus - physiology
Transcription, Genetic
Virology
Virus Replication
Virus
Tombusvirus
Recombination
Yeast
Plant pathogen
Tombusviridae
Microbiology
Identification
Virology
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Abstract Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon Twitter current issue Spotlights in the Current Issue JVI About JVI Subscribers Authors Reviewers Advertisers Inquiries from the Press Permissions & Commercial Reprints ASM Journals Public Access Policy JVI RSS Feeds 1752 N Street N.W. • Washington DC 20036 202.737.3600 • 202.942.9355 fax • journals@asmusa.org Print ISSN: 0022-538X Online ISSN: 1098-5514 Copyright © 2014 by the American Society for Microbiology.   For an alternate route to JVI .asm.org, visit: JVI       
AbstractList RNA recombination is a major process in promoting rapid virus evolution in an infected host. A previous genome-wide screen with the yeast single-gene deletion library of 4,848 strains, representing approximately 80% of all genes of yeast, led to the identification of 11 host genes affecting RNA recombination in Tomato bushy stunt virus (TBSV), a small model plant virus (E. Serviene, N. Shapka, C. P. Cheng, T. Panavas, B. Phuangrat, J. Baker, and P. D. Nagy, Proc. Natl. Acad. Sci. USA 102:10545-10550, 2005). To further test the role of host genes in viral RNA recombination, in this paper, we extended the screening to 800 essential yeast genes present in the yeast Tet-promoters Hughes Collection (yTHC). In total, we identified 16 new host genes that either increased or decreased the ratio of TBSV recombinants to the nonrecombined TBSV RNA. The identified essential yeast genes are involved in RNA transcription/metabolism, in protein metabolism/transport, or unknown cellular processes. Detailed analysis of the effect of the identified yeast genes revealed that they might affect RNA recombination by altering (i) the ratio of the two viral replication proteins, (ii) the stability of the viral RNA, and/or (iii) the replicability of the recombinant RNAs. Overall, this and previous works firmly establish that a set of essential and nonessential host genes could affect TBSV recombination and evolution.
RNA recombination is a major process in promoting rapid virus evolution in an infected host. A previous genome-wide screen with the yeast single-gene deletion library of 4,848 strains, representing similar to 80% of all genes of yeast, led to the identification of 11 host genes affecting RNA recombination in Tomato bushy stunt virus (TBSV), a small model plant virus (E. Serviene, N. Shapka, C. P. Cheng, T. Panavas, B. Phuangrat, J. Baker, and P. D. Nagy, Proc. Natl. Acad. Sci. USA 102:10545-10550, 2005). To further test the role of host genes in viral RNA recombination, in this paper, we extended the screening to 800 essential yeast genes present in the yeast Tet-promoters Hughes Collection (yTHC). In total, we identified 16 new host genes that either increased or decreased the ratio of TBSV recombinants to the nonrecombined TBSV RNA. The identified essential yeast genes are involved in RNA transcription/metabolism, in protein metabolism/transport, or unknown cellular processes. Detailed analysis of the effect of the identified yeast genes revealed that they might affect RNA recombination by altering (i) the ratio of the two viral replication proteins, (ii) the stability of the viral RNA, and/or (iii) the replicability of the recombinant RNAs. Overall, this and previous works firmly establish that a set of essential and nonessential host genes could affect TBSV recombination and evolution.
RNA recombination is a major process in promoting rapid virus evolution in an infected host. A previous genome-wide screen with the yeast single-gene deletion library of 4,848 strains, representing ∼80% of all genes of yeast, led to the identification of 11 host genes affecting RNA recombination in Tomato bushy stunt virus (TBSV), a small model plant virus (E. Serviene, N. Shapka, C. P. Cheng, T. Panavas, B. Phuangrat, J. Baker, and P. D. Nagy, Proc. Natl. Acad. Sci. USA 102: 10545-10550, 2005). To further test the role of host genes in viral RNA recombination, in this paper, we extended the screening to 800 essential yeast genes present in the yeast Tet-promoters Hughes Collection (yTHC). In total, we identified 16 new host genes that either increased or decreased the ratio of TBSV recombinants to the nonrecombined TBSV RNA. The identified essential yeast genes are involved in RNA transcription/metabolism, in protein metabolism/transport, or unknown cellular processes. Detailed analysis of the effect of the identified yeast genes revealed that they might affect RNA recombination by altering (i) the ratio of the two viral replication proteins, (ii) the stability of the viral RNA, and/or (iii) the replicability of the recombinant RNAs. Overall, this and previous works firmly establish that a set of essential and nonessential host genes could affect TBSV recombination and evolution.
ABSTRACT RNA recombination is a major process in promoting rapid virus evolution in an infected host. A previous genome-wide screen with the yeast single-gene deletion library of 4,848 strains, representing ∼80% of all genes of yeast, led to the identification of 11 host genes affecting RNA recombination in Tomato bushy stunt virus (TBSV), a small model plant virus (E. Serviene, N. Shapka, C. P. Cheng, T. Panavas, B. Phuangrat, J. Baker, and P. D. Nagy, Proc. Natl. Acad. Sci. USA 102: 10545-10550, 2005). To further test the role of host genes in viral RNA recombination, in this paper, we extended the screening to 800 essential yeast genes present in the yeast Tet-promoters Hughes Collection (yTHC). In total, we identified 16 new host genes that either increased or decreased the ratio of TBSV recombinants to the nonrecombined TBSV RNA. The identified essential yeast genes are involved in RNA transcription/metabolism, in protein metabolism/transport, or unknown cellular processes. Detailed analysis of the effect of the identified yeast genes revealed that they might affect RNA recombination by altering (i) the ratio of the two viral replication proteins, (ii) the stability of the viral RNA, and/or (iii) the replicability of the recombinant RNAs. Overall, this and previous works firmly establish that a set of essential and nonessential host genes could affect TBSV recombination and evolution.
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Author Elena Serviene
Chi-Ping Cheng
Yi Jiang
Peter D. Nagy
Jannine Baker
AuthorAffiliation Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, Kentucky 40546
AuthorAffiliation_xml – name: Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, Kentucky 40546
Author_xml – sequence: 1
  givenname: Elena
  surname: Serviene
  fullname: Serviene, Elena
  organization: Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546, USA
– sequence: 2
  givenname: Yi
  surname: Jiang
  fullname: Jiang, Yi
– sequence: 3
  givenname: Chi-Ping
  surname: Cheng
  fullname: Cheng, Chi-Ping
– sequence: 4
  givenname: Jannine
  surname: Baker
  fullname: Baker, Jannine
– sequence: 5
  givenname: Peter D
  surname: Nagy
  fullname: Nagy, Peter D
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https://www.ncbi.nlm.nih.gov/pubmed/16415000$$D View this record in MEDLINE/PubMed
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Issue 3
Keywords Virus
Tombusvirus
Recombination
Yeast
Plant pathogen
Tombusviridae
Microbiology
Identification
Virology
Language English
License CC BY 4.0
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Corresponding author. Mailing address: Department of Plant Pathology, University of Kentucky, Plant Science Building, Lexington, KY 40546. Phone: (869) 257-7445. Fax: (859) 323-1961. E-mail: pdnagy2@uky.edu.
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Snippet Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley...
RNA recombination is a major process in promoting rapid virus evolution in an infected host. A previous genome-wide screen with the yeast single-gene deletion...
ABSTRACT RNA recombination is a major process in promoting rapid virus evolution in an infected host. A previous genome-wide screen with the yeast single-gene...
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SourceType Open Access Repository
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StartPage 1231
SubjectTerms Base Sequence
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Genetic Diversity and Evolution
Genome, Fungal
Microbiology
Miscellaneous
Recombination, Genetic
Replicon
RNA, Fungal - genetics
RNA, Viral - genetics
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae - virology
Tomato bushy stunt virus
Tombusvirus
Tombusvirus - genetics
Tombusvirus - pathogenicity
Tombusvirus - physiology
Transcription, Genetic
Virology
Virus Replication
Title Screening of the Yeast yTHC Collection Identifies Essential Host Factors Affecting Tombusvirus RNA Recombination
URI http://jvi.asm.org/content/80/3/1231.abstract
https://www.ncbi.nlm.nih.gov/pubmed/16415000
https://search.proquest.com/docview/19824938
https://search.proquest.com/docview/70677561
https://pubmed.ncbi.nlm.nih.gov/PMC1346934
Volume 80
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